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dc.contributor.authorSilva, Vitória Regina Pereira dapt_BR
dc.contributor.authorSilva, Atailson Oliveira dapt_BR
dc.contributor.authorRodrigues , Mosar Corrêapt_BR
dc.contributor.authorPy-Daniel, Karen Rapppt_BR
dc.contributor.authorGomes, Bruna Rafaela Bezerrapt_BR
dc.contributor.authorDamas, Elysa Beatriz de Oliveirapt_BR
dc.contributor.authorNogueira, Thalya Soares Ribeiropt_BR
dc.contributor.authorVieira, Ivo José Curcinopt_BR
dc.contributor.authorCastro, Mariana de Souzapt_BR
dc.contributor.authorSousa, Marcelo Henriquept_BR
dc.contributor.authorCarneiro, Marcella Lemos Brettaspt_BR
dc.contributor.authorJoanitti, Graziella Anselmopt_BR
dc.date.accessioned2026-10-09T19:32:01Z-
dc.date.available2026-10-09T19:32:01Z-
dc.date.issued2026-10-2pt_BR
dc.identifier.citationSILVA, Vitória R. P. et al. Andiroba oil (*Carapa guianensis* Aublet) gel-based nanoemulsion: development, characterization, and In Vitro evaluation in wound healing-related cells. ACS Omega, 2026, p. A–N. DOI: https://doi.org/10.1021/acsomega.6c02635. Disponível em: https://doi.org/10.1021/acsomega.6c02635. Acesso em: 9 out. 2026.pt_BR
dc.identifier.urihttps://doi.org/10.1021/acsomega.6c02635pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/57200-
dc.publisherAmerican Chemical Society (ACS)pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleAndiroba Oil (Carapa guianensis Aublet) Gel-Based Nanoemulsion : Development, Characterization, and In Vitro Evaluation in Wound Healing-Related Cellspt_BR
dc.typeArtigopt_BR
dc.rights.licenseThis article is licensed under CC-BY 4.0en
dc.identifier.doihttps://doi.org/10.1021/acsomega.6c02635pt_BR
dc.description.abstract1Andiroba oil (Carapa guianensis Aublet) is widely used in traditional medicine due to its anti-inflammatory and reported wound-healing properties. In this study, we developed and characterized andiroba oil-based nanoemulsions (NeAnd) and gel-based nanostructured formulation (NeAndG) to investigate their physicochemical stability and initial in vitro biological effects in wound healing-related cells. Chemical characterization by GC-MS confirmed the presence of limonoids (including gedunin and its derivatives), β-sitosterol, and oleic acid in andiroba oil composition, compounds associated with anti-inflammatory and regenerative properties. The nanoemulsions exhibited hydrodynamic diameters <200 nm, low polydispersity indices (<0.3), and a negative surface charge, indicating a homogeneous and stable nanostructured system. After incorporation into the Carbopol hydrogel, the nanodroplets maintained nanoscale size while exhibiting a markedly increased negative ζ potential (≈ −74 mV), suggesting enhanced colloidal stability. Long-term stability assays demonstrated that the gel matrix significantly improved thermal stability and prevented nanodroplet aggregation compared with the nanoemulsion alone during storage (4, 25, and 37 °C for 120 days). In vitro assays using human keratinocytes (HaCaT) and fibroblasts (HGF) showed a dose-dependent decrease in cell viability. Scratch assay analysis revealed no significant enhancement of cell migration compared with controls, suggesting that the biological activity of andiroba oil in this context may involve mechanisms other than cell migration. Overall, these results demonstrate that the andiroba oil nanogel represents a stable and biocompatible nanoplatform suitable for further investigation in wound healing-related studies.en
dc.identifier.orcidhttps://orcid.org/0000-0001-7434-6491pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1210-8329pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6888-1284pt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano)pt_BR
dc.contributor.affiliationUniversity of Brasilia, Green Nanotechnology Grouppt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano)pt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano)pt_BR
dc.contributor.affiliationUniversity of Brasilia (UnB), Institute of Biological Sciences, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistrypt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano)pt_BR
dc.contributor.affiliationState University of Northern Fluminense, Laboratory of Chemical Sciences(LCQUI)pt_BR
dc.contributor.affiliationState University of Northern Fluminense, Laboratory of Chemical Sciences(LCQUI)pt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistry,pt_BR
dc.contributor.affiliationUniversity of Brasilia, Green Nanotechnology Grouppt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano), Graduation Program in Nanoscience and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano), Program in Pharmaceutical Science and Post-Graduation, Program in Nanoscience and Nanobiotechnologypt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)-
dc.description.unidadeDepartamento de Genética e Morfologia (IB GEM)-
dc.description.unidadeFaculdade de Ciências da Saúde (FS)-
dc.description.unidadeDepartamento de Farmácia (FS FAR)-
dc.description.ppgPrograma de Pós-Graduação em Nanociência e Nanobiotecnologia-
dc.description.ppgPrograma de Pós-Graduação em Ciências Farmacêuticas-
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