Title:	Sleep and memory complaints in long COVID : an insight into clustered psychological phenotypes
Authors:	Almeida, Ricardo Titze de Lacerda, Pedro Henrique Araújo Oliveira, Edson Pereira de Oliveira, Mariah Eduarda Ferreira de Vianna, Yngrid Sallaberry Silva Costa, Amanda Machado Santos, Eloísa Pereira dos Guérard, Louise Marie Coelho Ferreira, Matheus Augusto de Miranda Santos, Isabel Cristina Rodrigues dos Gonçalves, Jéssica Daniele da Silva Ferreira, Gabriel Ginani Almeida, Simoneide Souza Titze de Brandão, Pedro Renato de Paula Shimizu, Helena Eri Silva, Andrezza Paula Brito Rodrigues, Raimundo Nonato Delgado
metadata.dc.contributor.affiliation:	University of Brasília, Central Institute of Sciences, Research Center for Major Themes University of Brasília/FAV, Central Institute of Sciences, Technology for Gene Therapy Laboratory University of Brasília, Central Institute of Sciences, Research Center for Major Themes University of Brasília, Central Institute of Sciences, Research Center for Major Themes University of Brasília, Central Institute of Sciences, Research Center for Major Themes University of Brasília, Central Institute of Sciences, Research Center for Major Themes University of Brasília, Central Institute of Sciences, Research Center for Major Themes University of Brasília, Central Institute of Sciences, Research Center for Major Themes University of Brasília, Central Institute of Sciences, Research Center for Major Themes University of Brasília, Central Institute of Sciences, Research Center for Major Themes University of Brasília, Central Institute of Sciences, Research Center for Major Themes University of Brasília, Central Institute of Sciences, Research Center for Major Themes University of Brasília, Central Institute of Sciences, Research Center for Major Themes University of Brasília/FAV, Central Institute of Sciences, Technology for Gene Therapy Laboratory University of Brasília, Central Institute of Sciences, Research Center for Major Themes University of Brasília/FAV, Central Institute of Sciences, Technology for Gene Therapy Laboratory University of Brasília, Central Institute of Sciences, Research Center for Major Themes Sírio-Libanês Hospital, Brasília, Brazil University of Brasília, Department of Collective Health, Research Center for Major Themes University of Brasília, Central Institute of Sciences, Research Center for Major Themes University of Brasília, Central Institute of Sciences, Research Center for Major Themes
Assunto::	Covid-19 Pós-covid Biomarcadores Sono Depressão
Issue Date:	30-Jan-2024
Publisher:	PeerJ
Citation:	TITZE-DE-ALMEIDA, Ricardo et al. Sleep and memory complaints in long COVID: an insight into clustered psychological phenotypes. PeerJ, [S. l.], v. 12, e16669, 2024. DOI 10.7717/peerj.16669. DOI: https://doi.org/10.7717/peerj.16669. Disponível em: https://peerj.com/articles/16669/#aff-1. Acesso em: 24 set. 2026.
Abstract:	This study evaluated clinical features of individuals with long COVID (5-8 months after diagnosis) who reported sleep and memory problems (62 cases) compared to those without (52 controls). Both groups had a similar mean age (41 vs. 39 years). Around 86% of the participants were non-hospitalized at the time of infection, and none of them were vaccinated at that point. Subsequently, both cases and controls received the vaccine; however, the vaccination rates differed significantly between the groups (30.7% vs. 51.0%). Cases and controls had similar rates of symptoms at acute COVID phase. However, cases were more likely to experience coryza, dyspnea, headache, and nausea/vomiting during long COVID. Regarding new-onset symptoms in long COVID, 12.9% of cases had dyspnea, and 14.5% experienced nausea/vomiting, whereas in the control group there were only 1.9% and 0.0%, respectively. Cases also had a significantly higher prevalence of persistent headache (22.6% vs. 7.7%), and dyspnea (12.9% vs. 0.0). In addition, cases also showed an increased rate of mental health complaints: disability in daily activities (45.2% vs. 9.6%; P < 0.001); concentration/sustained attention difficulties (74.2% vs. 9.6%; P < 0.001); anxiety-Generalized Anxiety Disorder 2-item scale (GAD-2) ≥ 3 (66.1% vs. 34.6%; P = 0.0013); and "post-COVID sadness" (82.3% vs. 40.4%; P < 0.001). We observed a significant correlation between sadness and anxiety in cases, which was not observed in controls (P=0.0212; Spearman correlation test). Furthermore, the frequency of concomitant sadness and anxiety was markedly higher in cases compared to controls (59.7% vs. 19.2%) (P < 0.0001; Mann-Whitney test). These findings highlight a noteworthy association between sadness and anxiety specifically in cases. In conclusion, our data identified concurrent psychological phenotypes in individuals experiencing sleep and memory disturbances during long COVID. This strengthens the existing evidence that SARS-CoV-2 causes widespread brain pathology with interconnected phenotypic clusters. This finding highlights the need for comprehensive medical attention to address these complex issues, as well as major investments in testing strategies capable of preventing the development of long COVID sequelae, such as vaccination.
metadata.dc.description.unidade:	Faculdade de Ciências da Saúde (FS) Departamento de Saúde Coletiva (FS DSC) Faculdade de Agronomia e Medicina Veterinária (FAV) Centro de Pesquisa em Grandes Temas (CPGT)
metadata.dc.description.ppg:	Programa de Pós-Graduação em Bioética
Licença::	This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. Disponível em: https://peerj.com/articles/16669/#aff-1. Acesso em: 24/09/2026
DOI:	https://doi.org/10.7717/peerj.16669
Appears in Collections:	Artigos publicados em periódicos e afins

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