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dc.contributor.authorAlmeida, Ricardo Titze de-
dc.contributor.authorLacerda, Pedro Henrique Araújo-
dc.contributor.authorOliveira, Edson Pereira de-
dc.contributor.authorOliveira, Mariah Eduarda Ferreira de-
dc.contributor.authorVianna, Yngrid Sallaberry Silva-
dc.contributor.authorCosta, Amanda Machado-
dc.contributor.authorSantos, Eloísa Pereira dos-
dc.contributor.authorGuérard, Louise Marie Coelho-
dc.contributor.authorFerreira, Matheus Augusto de Miranda-
dc.contributor.authorSantos, Isabel Cristina Rodrigues dos-
dc.contributor.authorGonçalves, Jéssica Daniele da Silva-
dc.contributor.authorFerreira, Gabriel Ginani-
dc.contributor.authorAlmeida, Simoneide Souza Titze de-
dc.contributor.authorBrandão, Pedro Renato de Paula-
dc.contributor.authorShimizu, Helena Eri-
dc.contributor.authorSilva, Andrezza Paula Brito-
dc.contributor.authorRodrigues, Raimundo Nonato Delgado-
dc.date.accessioned2026-09-25T10:55:44Z-
dc.date.available2026-09-25T10:55:44Z-
dc.date.issued2024-01-30-
dc.identifier.citationTITZE-DE-ALMEIDA, Ricardo et al. Sleep and memory complaints in long COVID: an insight into clustered psychological phenotypes. PeerJ, [S. l.], v. 12, e16669, 2024. DOI 10.7717/peerj.16669. DOI: https://doi.org/10.7717/peerj.16669. Disponível em: https://peerj.com/articles/16669/#aff-1. Acesso em: 24 set. 2026.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/57005-
dc.language.isoengpt_BR
dc.publisherPeerJpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleSleep and memory complaints in long COVID : an insight into clustered psychological phenotypespt_BR
dc.typeArtigopt_BR
dc.subject.keywordCovid-19pt_BR
dc.subject.keywordPós-covidpt_BR
dc.subject.keywordBiomarcadorespt_BR
dc.subject.keywordSonopt_BR
dc.subject.keywordDepressãopt_BR
dc.rights.licenseThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. Disponível em: https://peerj.com/articles/16669/#aff-1. Acesso em: 24/09/2026pt_BR
dc.identifier.doihttps://doi.org/10.7717/peerj.16669pt_BR
dc.description.abstract1This study evaluated clinical features of individuals with long COVID (5-8 months after diagnosis) who reported sleep and memory problems (62 cases) compared to those without (52 controls). Both groups had a similar mean age (41 vs. 39 years). Around 86% of the participants were non-hospitalized at the time of infection, and none of them were vaccinated at that point. Subsequently, both cases and controls received the vaccine; however, the vaccination rates differed significantly between the groups (30.7% vs. 51.0%). Cases and controls had similar rates of symptoms at acute COVID phase. However, cases were more likely to experience coryza, dyspnea, headache, and nausea/vomiting during long COVID. Regarding new-onset symptoms in long COVID, 12.9% of cases had dyspnea, and 14.5% experienced nausea/vomiting, whereas in the control group there were only 1.9% and 0.0%, respectively. Cases also had a significantly higher prevalence of persistent headache (22.6% vs. 7.7%), and dyspnea (12.9% vs. 0.0). In addition, cases also showed an increased rate of mental health complaints: disability in daily activities (45.2% vs. 9.6%; P < 0.001); concentration/sustained attention difficulties (74.2% vs. 9.6%; P < 0.001); anxiety-Generalized Anxiety Disorder 2-item scale (GAD-2) ≥ 3 (66.1% vs. 34.6%; P = 0.0013); and "post-COVID sadness" (82.3% vs. 40.4%; P < 0.001). We observed a significant correlation between sadness and anxiety in cases, which was not observed in controls (P=0.0212; Spearman correlation test). Furthermore, the frequency of concomitant sadness and anxiety was markedly higher in cases compared to controls (59.7% vs. 19.2%) (P < 0.0001; Mann-Whitney test). These findings highlight a noteworthy association between sadness and anxiety specifically in cases. In conclusion, our data identified concurrent psychological phenotypes in individuals experiencing sleep and memory disturbances during long COVID. This strengthens the existing evidence that SARS-CoV-2 causes widespread brain pathology with interconnected phenotypic clusters. This finding highlights the need for comprehensive medical attention to address these complex issues, as well as major investments in testing strategies capable of preventing the development of long COVID sequelae, such as vaccination.pt_BR
dc.contributor.affiliationUniversity of Brasília, Central Institute of Sciences, Research Center for Major Themespt_BR
dc.contributor.affiliationUniversity of Brasília/FAV, Central Institute of Sciences, Technology for Gene Therapy Laboratorypt_BR
dc.contributor.affiliationUniversity of Brasília, Central Institute of Sciences, Research Center for Major Themespt_BR
dc.contributor.affiliationUniversity of Brasília, Central Institute of Sciences, Research Center for Major Themespt_BR
dc.contributor.affiliationUniversity of Brasília, Central Institute of Sciences, Research Center for Major Themespt_BR
dc.contributor.affiliationUniversity of Brasília, Central Institute of Sciences, Research Center for Major Themespt_BR
dc.contributor.affiliationUniversity of Brasília, Central Institute of Sciences, Research Center for Major Themespt_BR
dc.contributor.affiliationUniversity of Brasília, Central Institute of Sciences, Research Center for Major Themespt_BR
dc.contributor.affiliationUniversity of Brasília, Central Institute of Sciences, Research Center for Major Themespt_BR
dc.contributor.affiliationUniversity of Brasília, Central Institute of Sciences, Research Center for Major Themespt_BR
dc.contributor.affiliationUniversity of Brasília, Central Institute of Sciences, Research Center for Major Themespt_BR
dc.contributor.affiliationUniversity of Brasília, Central Institute of Sciences, Research Center for Major Themespt_BR
dc.contributor.affiliationUniversity of Brasília, Central Institute of Sciences, Research Center for Major Themespt_BR
dc.contributor.affiliationUniversity of Brasília/FAV, Central Institute of Sciences, Technology for Gene Therapy Laboratorypt_BR
dc.contributor.affiliationUniversity of Brasília, Central Institute of Sciences, Research Center for Major Themespt_BR
dc.contributor.affiliationUniversity of Brasília/FAV, Central Institute of Sciences, Technology for Gene Therapy Laboratorypt_BR
dc.contributor.affiliationUniversity of Brasília, Central Institute of Sciences, Research Center for Major Themespt_BR
dc.contributor.affiliationSírio-Libanês Hospital, Brasília, Brazilpt_BR
dc.contributor.affiliationUniversity of Brasília, Department of Collective Health, Research Center for Major Themespt_BR
dc.contributor.affiliationUniversity of Brasília, Central Institute of Sciences, Research Center for Major Themespt_BR
dc.contributor.affiliationUniversity of Brasília, Central Institute of Sciences, Research Center for Major Themespt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Saúde Coletiva (FS DSC)pt_BR
dc.description.unidadeFaculdade de Agronomia e Medicina Veterinária (FAV)pt_BR
dc.description.unidadeCentro de Pesquisa em Grandes Temas (CPGT)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Bioéticapt_BR
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