Title:	Exploring the therapeutic potential of an antinociceptive and anti-inflammatory peptide from wasp venom
Authors:	Galante, Priscilla Campos, Gabriel Avohay Alves Moser, Jacqueline Coimbra Gonçalves Martins, Danubia B. Cabrera, Marcia P. dos Santos Rangel, Marisa Coelho, Luiza C. Simon, Karina Smidt Amado, Veronica Moreira Muller, Jessica de A. I. Koehbach, Johannes Lohman, Rink-Jan Cabot, Peter J. Vetter, Irina Craik, David J. Kadri, Monica C. Toffoli Monge Fuentes, Victoria Goulart, Jair Trape Schwartz, Elisabeth Nogueira Ferroni Silva, Luciano P. Bocca, Anamelia Lorenzetti Mortari, Márcia Renata
metadata.dc.contributor.affiliation:	The University of Queensland, Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science The University of Queensland, School of Pharmacy The University of Queensland, School of Pharmacy The University of Queensland, Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science The University of Queensland, Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science Federal University of Mato Grosso do Sul, Laboratory of Pharmacology and Inflammation FACFAN University of Brasília, Department of Physiological Sciences, Laboratory of Neuropharmacology University of Brasília, Department of Physiological Sciences, Laboratory of Neuropharmacology University of Brasília, Department of Physiological Sciences, Laboratory of Neuropharmacology Embrapa Genetic Resources and Biotechnology, Laboratory of Nanobiotechnology University of Brasília, Department of Physiological Sciences, Laboratory of Neuropharmacology University of Brasília, Department of Physiological Sciences, Laboratory of Neuropharmacology University of Brasília, Department of Physiological Sciences, Laboratory of Neuropharmacology São Paulo State University, São José do Rio Preto, SP, Department of Physics, IBILCE São Paulo State University, São José do Rio Preto, SP, Department of Physics, IBILCE Butantan Institute, Immunopathology Laboratory University of Brasilia, Department of Cell Biology, Laboratory of Applied Immunology University of Brasilia, Department of Cell Biology, Laboratory of Applied Immunology University of Brasilia, Faculty of Medicine and University Hospital of Brasília Federal University of Mato Grosso do Sul, Laboratory of Pharmacology and Inflammation FACFAN
Assunto::	Neurofarmacologia Anti-inflamatórios Dor Peptídeos Vespa - veneno Biotecnologia
Issue Date:	1-Aug-2023
Publisher:	Springer Science and Business Media LLC
Citation:	GALANTE, Priscilla et al. Exploring the therapeutic potential of an antinociceptive and anti-inflammatory peptide from wasp venom. Scientific Reports, [S. l.], v. 13, n. 1, 12491, 2023. DOI: https://doi.org/10.1038/s41598-023-38828-w. Disponível em: http://dx.doi.org/10.1038/s41598-023-38828-w. Acesso em: 27 ago. 2026.
Abstract:	Animal venoms are rich sources of neuroactive compounds, including anti-inflammatory, antiepileptic, and antinociceptive molecules. Our study identified a protonectin peptide from the wasp Parachartergus fraternus' venom using mass spectrometry and cDNA library construction. Using this peptide as a template, we designed a new peptide, protonectin-F, which exhibited higher antinociceptive activity and less motor impairment compared to protonectin. In drug interaction experiments with naloxone and AM251, Protonectin-F's activity was decreased by opioid and cannabinoid antagonism, two critical antinociception pathways. Further experiments revealed that this effect is most likely not induced by direct action on receptors but by activation of the descending pain control pathway. We noted that protonectin-F induced less tolerance in mice after repeated administration than morphine. Protonectin-F was also able to decrease TNF-α production in vitro and modulate the inflammatory response, which can further contribute to its antinociceptive activity. These findings suggest that protonectin-F may be a potential molecule for developing drugs to treat pain disorders with fewer adverse effects. Our results reinforce the biotechnological importance of animal venom for developing new molecules of clinical interest.
metadata.dc.description.unidade:	Instituto de Ciências Biológicas (IB) Departamento de Ciências Fisiológicas (IB CFS) Departamento de Biologia Celular (IB CEL)
DOI:	https://doi.org/10.1038/s41598-023-38828-w
Appears in Collections:	Artigos publicados em periódicos e afins

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