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dc.contributor.authorGalante, Priscilla-
dc.contributor.authorCampos, Gabriel Avohay Alves-
dc.contributor.authorMoser, Jacqueline Coimbra Gonçalves-
dc.contributor.authorMartins, Danubia B.-
dc.contributor.authorCabrera, Marcia P. dos Santos-
dc.contributor.authorRangel, Marisa-
dc.contributor.authorCoelho, Luiza C.-
dc.contributor.authorSimon, Karina Smidt-
dc.contributor.authorAmado, Veronica Moreira-
dc.contributor.authorMuller, Jessica de A. I.-
dc.contributor.authorKoehbach, Johannes-
dc.contributor.authorLohman, Rink-Jan-
dc.contributor.authorCabot, Peter J.-
dc.contributor.authorVetter, Irina-
dc.contributor.authorCraik, David J.-
dc.contributor.authorKadri, Monica C. Toffoli-
dc.contributor.authorMonge Fuentes, Victoria-
dc.contributor.authorGoulart, Jair Trape-
dc.contributor.authorSchwartz, Elisabeth Nogueira Ferroni-
dc.contributor.authorSilva, Luciano P.-
dc.contributor.authorBocca, Anamelia Lorenzetti-
dc.contributor.authorMortari, Márcia Renata-
dc.date.accessioned2026-08-28T11:10:27Z-
dc.date.available2026-08-28T11:10:27Z-
dc.date.issued2023-08-01-
dc.identifier.citationGALANTE, Priscilla et al. Exploring the therapeutic potential of an antinociceptive and anti-inflammatory peptide from wasp venom. Scientific Reports, [S. l.], v. 13, n. 1, 12491, 2023. DOI: https://doi.org/10.1038/s41598-023-38828-w. Disponível em: http://dx.doi.org/10.1038/s41598-023-38828-w. Acesso em: 27 ago. 2026.pt_BR
dc.identifier.issnhttp://dx.doi.org/10.1038/s41598-023-38828-w-
dc.identifier.issnhttp://dx.doi.org/10.1038/s41598-023-38828-w-
dc.identifier.urihttp://dx.doi.org/10.1038/s41598-023-38828-wpt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/55752-
dc.language.isoengpt_BR
dc.publisherSpringer Science and Business Media LLCpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleExploring the therapeutic potential of an antinociceptive and anti-inflammatory peptide from wasp venompt_BR
dc.typeArtigopt_BR
dc.subject.keywordNeurofarmacologiapt_BR
dc.subject.keywordAnti-inflamatóriospt_BR
dc.subject.keywordDorpt_BR
dc.subject.keywordPeptídeospt_BR
dc.subject.keywordVespa - venenopt_BR
dc.subject.keywordBiotecnologiapt_BR
dc.identifier.doihttps://doi.org/10.1038/s41598-023-38828-wpt_BR
dc.description.abstract1Animal venoms are rich sources of neuroactive compounds, including anti-inflammatory, antiepileptic, and antinociceptive molecules. Our study identified a protonectin peptide from the wasp Parachartergus fraternus' venom using mass spectrometry and cDNA library construction. Using this peptide as a template, we designed a new peptide, protonectin-F, which exhibited higher antinociceptive activity and less motor impairment compared to protonectin. In drug interaction experiments with naloxone and AM251, Protonectin-F's activity was decreased by opioid and cannabinoid antagonism, two critical antinociception pathways. Further experiments revealed that this effect is most likely not induced by direct action on receptors but by activation of the descending pain control pathway. We noted that protonectin-F induced less tolerance in mice after repeated administration than morphine. Protonectin-F was also able to decrease TNF-α production in vitro and modulate the inflammatory response, which can further contribute to its antinociceptive activity. These findings suggest that protonectin-F may be a potential molecule for developing drugs to treat pain disorders with fewer adverse effects. Our results reinforce the biotechnological importance of animal venom for developing new molecules of clinical interest.pt_BR
dc.contributor.affiliationThe University of Queensland, Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Sciencept_BR
dc.contributor.affiliationThe University of Queensland, School of Pharmacypt_BR
dc.contributor.affiliationThe University of Queensland, School of Pharmacypt_BR
dc.contributor.affiliationThe University of Queensland, Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Sciencept_BR
dc.contributor.affiliationThe University of Queensland, Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Sciencept_BR
dc.contributor.affiliationFederal University of Mato Grosso do Sul, Laboratory of Pharmacology and Inflammation FACFANpt_BR
dc.contributor.affiliationUniversity of Brasília, Department of Physiological Sciences, Laboratory of Neuropharmacologypt_BR
dc.contributor.affiliationUniversity of Brasília, Department of Physiological Sciences, Laboratory of Neuropharmacologypt_BR
dc.contributor.affiliationUniversity of Brasília, Department of Physiological Sciences, Laboratory of Neuropharmacologypt_BR
dc.contributor.affiliationEmbrapa Genetic Resources and Biotechnology, Laboratory of Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasília, Department of Physiological Sciences, Laboratory of Neuropharmacologypt_BR
dc.contributor.affiliationUniversity of Brasília, Department of Physiological Sciences, Laboratory of Neuropharmacologypt_BR
dc.contributor.affiliationUniversity of Brasília, Department of Physiological Sciences, Laboratory of Neuropharmacologypt_BR
dc.contributor.affiliationSão Paulo State University, São José do Rio Preto, SP, Department of Physics, IBILCEpt_BR
dc.contributor.affiliationSão Paulo State University, São José do Rio Preto, SP, Department of Physics, IBILCEpt_BR
dc.contributor.affiliationButantan Institute, Immunopathology Laboratorypt_BR
dc.contributor.affiliationUniversity of Brasilia, Department of Cell Biology, Laboratory of Applied Immunologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Department of Cell Biology, Laboratory of Applied Immunologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Medicine and University Hospital of Brasíliapt_BR
dc.contributor.affiliationFederal University of Mato Grosso do Sul, Laboratory of Pharmacology and Inflammation FACFANpt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)pt_BR
dc.description.unidadeDepartamento de Ciências Fisiológicas (IB CFS)pt_BR
dc.description.unidadeDepartamento de Biologia Celular (IB CEL)pt_BR
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