Title:	The relevance of telomerase and telomere-associated proteins in b-acute lymphoblastic leukemia
Authors:	Mota, Tales Henrique Andrade da Camargo, Ricardo Biojone, Estefânia Rodrigues Guimarães, Ana Flávia Reis Pittella-Silva, Fabio Oliveira, Diêgo Madureira de
metadata.dc.identifier.orcid:	https://orcid.org/0000-0001-9299-9410 https://orcid.org/0000-0003-0592-8396 https://orcid.org/0000-0002-9644-7098 https://orcid.org/0000-0002-6044-1954
metadata.dc.contributor.affiliation:	Laboratory of Molecular Pathology of Cancer, University of Brasilia Laboratory of Molecular Analysis, Faculty of Ceilândia, University of Brasilia Brasília Children’s Hospital José Alencar Brasília Children’s Hospital José Alencar Laboratory of Molecular Analysis, Faculty of Ceilândia, University of Brasilia Laboratory of Molecular Pathology of Cancer, University of Brasilia Laboratory of Molecular Pathology of Cancer, University of Brasilia
Assunto::	Telomerase Telômero Leucemia
Issue Date:	10-Mar-2023
Publisher:	MDPI AG
Citation:	MOTA, Tales Henrique Andrade da; CAMARGO, Ricardo; BIOJONE, Estefânia Rodrigues; GUIMARÃES, Ana Flávia Reis; PITTELLA-SILVA, Fabio; OLIVEIRA, Diêgo Madureira de. The relevance of telomerase and telomere-associated proteins in b-acute lymphoblastic leukemia. Genes, v. 14, n. 3, p. 691, 2023. DOI: https://doi.org/10.3390/genes14030691. Disponível em: https://doi.org/10.3390/genes14030691. Acesso em: 10 jun. 2026.
Abstract:	Telomeres and telomerase are closely linked to uncontrolled cellular proliferation, immortalization and carcinogenesis. Telomerase has been largely studied in the context of cancer, including leukemias. Deregulation of human telomerase gene hTERT is a well-established step in leukemia development. B-acute lymphoblastic leukemia (B-ALL) recovery rates exceed 90% in children; however, the relapse rate is around 20% among treated patients, and 10% of these are still incurable. This review highlights the biological and clinical relevance of telomerase for B-ALL and the implications of its canonical and non-canonical action on signaling pathways in the context of disease and treatment. The physiological role of telomerase in lymphocytes makes the study of its biomarker potential a great challenge. Nevertheless, many works have demonstrated that high telomerase activity or hTERT expression, as well as short telomeres, correlate with poor prognosis in B-ALL. Telomerase and related proteins have been proven to be promising pharmacological targets. Likewise, combined therapy with telomerase inhibitors may turn out to be an alternative strategy for B-ALL.
metadata.dc.description.unidade:	Faculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB Ceilândia
metadata.dc.description.ppg:	Programa de Pós-Graduação em Ciências e Tecnologias em Saúde
Licença::	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). FONTE: https://www.mdpi.com/2073-4425/14/3/691. Acesso em: 10 jun. 2026.
DOI:	https://doi.org/10.3390/genes14030691
metadata.dc.relation.publisherversion:	https://www.mdpi.com/2073-4425/14/3/691
Appears in Collections:	Artigos publicados em periódicos e afins

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