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dc.contributor.authorMota, Tales Henrique Andrade dapt_BR
dc.contributor.authorCamargo, Ricardopt_BR
dc.contributor.authorBiojone, Estefânia Rodriguespt_BR
dc.contributor.authorGuimarães, Ana Flávia Reispt_BR
dc.contributor.authorPittella-Silva, Fabiopt_BR
dc.contributor.authorOliveira, Diêgo Madureira dept_BR
dc.date.accessioned2026-06-10T22:22:27Z-
dc.date.available2026-06-10T22:22:27Z-
dc.date.issued2023-3-10pt_BR
dc.identifier.citationMOTA, Tales Henrique Andrade da; CAMARGO, Ricardo; BIOJONE, Estefânia Rodrigues; GUIMARÃES, Ana Flávia Reis; PITTELLA-SILVA, Fabio; OLIVEIRA, Diêgo Madureira de. The relevance of telomerase and telomere-associated proteins in b-acute lymphoblastic leukemia. Genes, v. 14, n. 3, p. 691, 2023. DOI: https://doi.org/10.3390/genes14030691. Disponível em: https://doi.org/10.3390/genes14030691. Acesso em: 10 jun. 2026.pt_BR
dc.identifier.urihttps://doi.org/10.3390/genes14030691pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/54727-
dc.publisherMDPI AGpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleThe relevance of telomerase and telomere-associated proteins in b-acute lymphoblastic leukemiapt_BR
dc.typeArtigopt_BR
dc.subject.keywordTelomerasept_BR
dc.subject.keywordTelômeropt_BR
dc.subject.keywordLeucemiapt_BR
dc.rights.licenseThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). FONTE: https://www.mdpi.com/2073-4425/14/3/691. Acesso em: 10 jun. 2026.pt_BR
dc.identifier.doihttps://doi.org/10.3390/genes14030691pt_BR
dc.relation.publisherversionhttps://www.mdpi.com/2073-4425/14/3/691pt_BR
dc.description.abstract1Telomeres and telomerase are closely linked to uncontrolled cellular proliferation, immortalization and carcinogenesis. Telomerase has been largely studied in the context of cancer, including leukemias. Deregulation of human telomerase gene hTERT is a well-established step in leukemia development. B-acute lymphoblastic leukemia (B-ALL) recovery rates exceed 90% in children; however, the relapse rate is around 20% among treated patients, and 10% of these are still incurable. This review highlights the biological and clinical relevance of telomerase for B-ALL and the implications of its canonical and non-canonical action on signaling pathways in the context of disease and treatment. The physiological role of telomerase in lymphocytes makes the study of its biomarker potential a great challenge. Nevertheless, many works have demonstrated that high telomerase activity or hTERT expression, as well as short telomeres, correlate with poor prognosis in B-ALL. Telomerase and related proteins have been proven to be promising pharmacological targets. Likewise, combined therapy with telomerase inhibitors may turn out to be an alternative strategy for B-ALL.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9299-9410pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0592-8396pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9644-7098pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6044-1954pt_BR
dc.contributor.affiliationLaboratory of Molecular Pathology of Cancer, University of Brasiliapt_BR
dc.contributor.affiliationLaboratory of Molecular Analysis, Faculty of Ceilândia, University of Brasiliapt_BR
dc.contributor.affiliationBrasília Children’s Hospital José Alencarpt_BR
dc.contributor.affiliationBrasília Children’s Hospital José Alencarpt_BR
dc.contributor.affiliationLaboratory of Molecular Analysis, Faculty of Ceilândia, University of Brasiliapt_BR
dc.contributor.affiliationLaboratory of Molecular Pathology of Cancer, University of Brasiliapt_BR
dc.contributor.affiliationLaboratory of Molecular Pathology of Cancer, University of Brasiliapt_BR
dc.description.unidadeFaculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB Ceilândiapt_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências e Tecnologias em Saúdept_BR
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