Skip navigation
Universidade de Brasília
Use este identificador para citar ou linkar para este item: http://repositorio.unb.br/handle/10482/57307
Arquivos associados a este item:
Não existem arquivos associados a este item.
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorSilva, Nádija N. P. da Silva-
dc.contributor.authorMello, Marcos Vinicius Palmeira-
dc.contributor.authorAcésio, Nathália O.-
dc.contributor.authorMoraes, Carlos A. F.-
dc.contributor.authorAraújo Neto, João Honorato de-
dc.contributor.authorCastellano, Eduardo E.-
dc.contributor.authorTavares, Denise C.-
dc.contributor.authorOliveira, Katia Mara de-
dc.contributor.authorBatista, Alzir A.-
dc.date.accessioned2026-10-21T15:41:34Z-
dc.date.available2026-10-21T15:41:34Z-
dc.date.issued2025-
dc.identifier.citationSILVA, Nádija N. P. da et al. Ru(ii)-diphosphine/N,S-mercapto complexes and their anti-melanoma properties. Dalton Transactions, [S. l.], v. 54, n. 2, p. 605-615, 2025. DOI: https://doi.org/10.1039/d4dt02575j.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/57307-
dc.language.isoengpt_BR
dc.publisherRoyal Society of Chemistrypt_BR
dc.rightsAcesso Restritopt_BR
dc.titleRu(II)-diphosphine/N,S-mercapto complexes and their anti-melanoma propertiespt_BR
dc.typeArtigopt_BR
dc.subject.keywordComplexos de rutênio(II)pt_BR
dc.subject.keywordAtividade antitumoralpt_BR
dc.subject.keywordMelanomapt_BR
dc.identifier.doihttps://doi.org/10.1039/d4dt02575jpt_BR
dc.relation.publisherversionhttps://pubs.rsc.org/dt/article/54/2/605/847525/Ru-ii-diphosphine-N-S-mercapto-complexes-and-theirpt_BR
dc.description.abstract1We have synthesized and characterized a novel series of ruthenium complexes with formulas [RuCl(N–S)(dppm)2]PF6 (Ru1), [Ru(N–S)(dppm)2]PF6 (Ru2), [Ru(N–S)(dppe)2]PF6 (Ru3), [Ru(N–S)(dppen)2]PF6 (Ru4), [Ru(N–S)(bpy)2]PF6 (Ru5). In these formulas, N–S or S represents H2mq (2-mercapto-4(3H)-quinazoline); dppe (1,2′-bis(diphenylphosphine)ethane), dppm (1,1′-bis(diphenylphosphine)methane), or dppen (1,2′-bis(diphenylphosphine)ethene); and bpy refers to 2,2′-bipyridine. We have also compared the cytotoxicity of cisplatin with these ruthenium complexes to murine melanoma cells (B16-F10), human melanoma cells (A-375), and the non-tumoral human keratinocyte cell line (HaCat). All the ruthenium complexes inhibited melanoma cell growth in a dose-dependent manner. [Ru(2mq)(dppen)2]PF6 was four times more active toward A-375 cells than toward HaCat cells, inhibited colony formation in HaCat and A-375 cells (with a more pronounced effect on A-375 cells), altered A-375 cell morphology, and inhibited cell migration at 0.2 and 0.4 μM. In addition, we investigated how these ruthenium complexes interact with biomolecules such as DNA and Human Serum Albumin (HSA). All the ruthenium complexes interacted weakly with DNA, possibly through the grooves. Based on fluorescence assays, the ruthenium complexes interacted moderately with HSA. In light of these results, ruthenium complexes bearing phosphine and H2mq display promising cytotoxic properties against melanoma.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2550-5315pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1127-6083pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4749-0281pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4671-2754pt_BR
dc.contributor.affiliationFederal University of São Carlos, Departament of Chemistrypt_BR
dc.contributor.affiliationFederal University of São Carlos, Departament of Chemistrypt_BR
dc.contributor.affiliationUniversity of Francapt_BR
dc.contributor.affiliationFederal University of São Carlos, Departament of Chemistrypt_BR
dc.contributor.affiliationFederal University of São Carlos, Physics Institutept_BR
dc.contributor.affiliationFederal University of São Carlos, Physics Institutept_BR
dc.contributor.affiliationUniversity of Francapt_BR
dc.contributor.affiliationFederal University of São Carlos, Departament of Chemistrypt_BR
dc.description.unidadeInstituto de Química (IQ)pt_BR
Aparece nas coleções:Artigos publicados em periódicos e afins

Mostrar registro simples do item Visualizar estatísticas



Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.