Título:	Variantes genéticas (VNTR) 3'UTR SLC6A3 e NOS3 intron 4 no transtorno depressivo maior
Autor(es):	Gontijo, Bruna Rodrigues
Orientador(es):	Silva, Izabel Cristina Rodrigues da
Assunto:	Transtorno depressivo maior Óxido Nítrico Polimorfismo genético
Data de publicação:	29-Jun-2026
Data de defesa:	31-Jul-2023
Referência:	GONTIJO, Bruna Rodrigues. Variantes genéticas (VNTR) 3'UTR SLC6A3 e NOS3 intron 4 no transtorno depressivo maior. 2023. 137 f., il. Dissertação (Mestrado em Ciências e Tecnologias em Saúde) — Universidade de Brasília, Brasília, 2023.
Abstract:	Major Depressive Disorder is a disabling condition that interferes with the individual's cognition and psychosocial functioning, with a higher incidence in females than in males. Among the symptoms are sadness, hopelessness, exhaustion, depressed mood, anhedonia and behavioral changes. The development of the disease has a multifactorial character in which there is the involvement of social, cultural, biological and genetic parameters. Thus, the present work aimed to verify the genotypic fluctuation and the influence of the genetic variant 3'UTR SLC6A3 VNTR in populations with MDD, through a systematic review, in addition to identifying and analyzing the polymorphism in intron 4 of the NOS3 gene, in patients with MDD undergoing treatment for at least 3 months at CAPS III in Samambaia Sul - DF. For the development of the systematic review, a search for articles was carried out in the databases: Pubmed, Web of Science, Virtual Health Library (BVS) and Scopus and, through selection by pre-established inclusion and exclusion criteria, 6 studies were chosen. Regarding the cross-sectional, descriptive and case-control study, blood samples were collected from 13 patients in the case group and 81 in the control group. These samples were submitted to Polymerase Chain Reaction (PCR) for further genotyping. A significance level of 5% was adopted. Regarding the results found, in the systematic review of the SLC6A3 (DAT1) 3'UTR VNTR gene, an association was observed between the SS (9R/9R) genotype and the presence of the S (9R) allele with the risk of developing TDM, in addition to influence the decrease in response to antidepressant therapy. In addition, in the case-control study regarding the NOS3 INTRON 4 VNTR gene, a statistically significant difference was observed in the genotype distribution between individuals with MDD and healthy individuals, considering that the presence of the b/b genotype is a protective factor for the disease development. There was also a correlation between the a/a and a/b genotype with high cholesterol and the b/b genotype with high glucose in patients who had MDD. Therefore, as it is a multifactorial disease, it becomes increasingly essential to establish new studies of genetic polymorphisms in order to improve the diagnosis, treatment and quality of life of patients.
Unidade Acadêmica:	Faculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB Ceilândia
Informações adicionais:	Dissertação (mestrado) — Universidade de Brasília, Faculdade de Ceilândia, Programa de Pós-Graduação em Ciências e Tecnologias em Saúde, 2023.
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências e Tecnologias em Saúde
Agência financiadora:	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Aparece nas coleções:	Teses, dissertações e produtos pós-doutorado

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