Título:	Grape seed oil microemulsion for improved skin delivery of resveratrol
Autor(es):	Nogueira, Mariana A. P. C. Cardoso, Camila Oliveira Albuquerque, Lucas Fraga Friaça Cunha Filho, Marcílio Sérgio Soares da Gratieri, Taís Gelfuso, Guilherme Martins
ORCID:	https://orcid.org/0000-0002-1924-7885
Afiliação do autor:	University of Brasília, School of Health Sciences, Laboratory of Food, Drug and Cosmetics (LTMAC) University of Brasília, School of Health Sciences, Laboratory of Food, Drug and Cosmetics (LTMAC) University of Brasília, School of Health Sciences, Laboratory of Food, Drug and Cosmetics (LTMAC) University of Brasília, School of Health Sciences, Laboratory of Food, Drug and Cosmetics (LTMAC) University of Brasília, School of Health Sciences, Laboratory of Food, Drug and Cosmetics (LTMAC) University of Brasília, School of Health Sciences, Laboratory of Food, Drug and Cosmetics (LTMAC)
Assunto:	Farmacologia Resveratrol Permeação cutânea
Data de publicação:	2025
Editora:	Springer Nature
Referência:	NOGUEIRA, Marianne A. P. C. et al. Grape seed oil microemulsion for improved skin delivery of resveratrol. AAPS PharmSciTech, [S. L.], v. 26, n. 148, 2025. DOI: https://doi.org/10.1208/s12249-025-03146-z.
Abstract:	Given the anti-inflammatory properties of Resveratrol, this paper proposes developing a grape seed oil-in-water microemulsion (ME) for topical administration to treat inflammatory skin pathological conditions. Thermal analyses confirmed compatibility between Resveratrol, grape seed oil, Tween 80, and Span 80 used in the formulations. Two compositions (ME1 and ME2) were selected from a pseudo-ternary diagram prepared by components titration. ME1 (50% water, 35% surfactant, 15% oil) and ME2 (60% water, 30% surfactant, 10% oil) showed mean droplet sizes of 23.1 ± 0.7 nm and 24.9 ± 1.7 nm (PdI = 0.34 and 0.47), zeta potential between -11.7 ± 0.5 and -13.6 ± 0.9 mV, and pH values of 6.2 ± 0.5 and 7.1 ± 1.1, respectively. Rheological analyses revealed Newtonian behavior and low viscosity, with physical stability for 60 days at room temperature. In vitro drug permeation studies using porcine skin demonstrated that ME increased Resveratrol penetration into deeper skin layers by fourfold (p < 0.001) compared to the control solution (ME1: 2.9 ± 0.1 μg/cm2, ME2: 2.4 ± 0.1 μg/cm2), while reducing retention in the stratum corneum. HET-CAM experiments indicated safety for topical application. In conclusion, the ME was a promising alternative for future clinical investigations to treat inflammatory skin conditions.
Unidade Acadêmica:	Faculdade de Ciências da Saúde (FS) Departamento de Farmácia (FS FAR)
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências Farmacêuticas
DOI:	https://doi.org/10.1208/s12249-025-03146-z
Versão da editora:	https://link.springer.com/article/10.1208/s12249-025-03146-z
Aparece nas coleções:	Artigos publicados em periódicos e afins

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