Grape seed oil microemulsion for improved skin delivery  of resveratrol

Nogueira, Mariana A. P. C.; Cardoso, Camila Oliveira; Albuquerque, Lucas Fraga Friaça; Cunha Filho, Marcílio Sérgio Soares da; Gratieri, Taís; Gelfuso, Guilherme Martins

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Campo DC	Valor	Idioma
dc.contributor.author	Nogueira, Mariana A. P. C.	-
dc.contributor.author	Cardoso, Camila Oliveira	-
dc.contributor.author	Albuquerque, Lucas Fraga Friaça	-
dc.contributor.author	Cunha Filho, Marcílio Sérgio Soares da	-
dc.contributor.author	Gratieri, Taís	-
dc.contributor.author	Gelfuso, Guilherme Martins	-
dc.date.accessioned	2025-10-28T13:30:17Z	-
dc.date.available	2025-10-28T13:30:17Z	-
dc.date.issued	2025	-
dc.identifier.citation	NOGUEIRA, Marianne A. P. C. et al. Grape seed oil microemulsion for improved skin delivery of resveratrol. AAPS PharmSciTech, [S. L.], v. 26, n. 148, 2025. DOI: https://doi.org/10.1208/s12249-025-03146-z.	pt_BR
dc.identifier.uri	http://repositorio.unb.br/handle/10482/52932	-
dc.language.iso	eng	pt_BR
dc.publisher	Springer Nature	pt_BR
dc.rights	Acesso Restrito	pt_BR
dc.title	Grape seed oil microemulsion for improved skin delivery of resveratrol	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Farmacologia	pt_BR
dc.subject.keyword	Resveratrol	pt_BR
dc.subject.keyword	Permeação cutânea	pt_BR
dc.identifier.doi	https://doi.org/10.1208/s12249-025-03146-z	pt_BR
dc.relation.publisherversion	https://link.springer.com/article/10.1208/s12249-025-03146-z	pt_BR
dc.description.abstract1	Given the anti-inflammatory properties of Resveratrol, this paper proposes developing a grape seed oil-in-water microemulsion (ME) for topical administration to treat inflammatory skin pathological conditions. Thermal analyses confirmed compatibility between Resveratrol, grape seed oil, Tween 80, and Span 80 used in the formulations. Two compositions (ME1 and ME2) were selected from a pseudo-ternary diagram prepared by components titration. ME1 (50% water, 35% surfactant, 15% oil) and ME2 (60% water, 30% surfactant, 10% oil) showed mean droplet sizes of 23.1 ± 0.7 nm and 24.9 ± 1.7 nm (PdI = 0.34 and 0.47), zeta potential between -11.7 ± 0.5 and -13.6 ± 0.9 mV, and pH values of 6.2 ± 0.5 and 7.1 ± 1.1, respectively. Rheological analyses revealed Newtonian behavior and low viscosity, with physical stability for 60 days at room temperature. In vitro drug permeation studies using porcine skin demonstrated that ME increased Resveratrol penetration into deeper skin layers by fourfold (p < 0.001) compared to the control solution (ME1: 2.9 ± 0.1 μg/cm2, ME2: 2.4 ± 0.1 μg/cm2), while reducing retention in the stratum corneum. HET-CAM experiments indicated safety for topical application. In conclusion, the ME was a promising alternative for future clinical investigations to treat inflammatory skin conditions.	pt_BR
dc.identifier.orcid	https://orcid.org/0000-0002-1924-7885	pt_BR
dc.contributor.affiliation	University of Brasília, School of Health Sciences, Laboratory of Food, Drug and Cosmetics (LTMAC)	pt_BR
dc.contributor.affiliation	University of Brasília, School of Health Sciences, Laboratory of Food, Drug and Cosmetics (LTMAC)	pt_BR
dc.contributor.affiliation	University of Brasília, School of Health Sciences, Laboratory of Food, Drug and Cosmetics (LTMAC)	pt_BR
dc.contributor.affiliation	University of Brasília, School of Health Sciences, Laboratory of Food, Drug and Cosmetics (LTMAC)	pt_BR
dc.contributor.affiliation	University of Brasília, School of Health Sciences, Laboratory of Food, Drug and Cosmetics (LTMAC)	pt_BR
dc.contributor.affiliation	University of Brasília, School of Health Sciences, Laboratory of Food, Drug and Cosmetics (LTMAC)	pt_BR
dc.description.unidade	Faculdade de Ciências da Saúde (FS)	pt_BR
dc.description.unidade	Departamento de Farmácia (FS FAR)	pt_BR
dc.description.ppg	Programa de Pós-Graduação em Ciências Farmacêuticas	pt_BR
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