Título :	Papel do receptor taquicinérgico NK3, via agonista senktide, na sensitização comportamental induzida pela administração repetida de cocaína em micos-estrela
Autor :	Melamed, Jonathan Lobo
Orientador(es)::	Barros, Marília
Assunto::	Primata - comportamento - avaliação Drogas - abuso Drogas - efeitos
Fecha de publicación :	20-abr-2012
Data de defesa::	8-dic-2011
Citación :	MELAMED, Jonathan Lobo. Papel do receptor taquicinérgico NK3, via agonista senktide, na sensitização comportamental induzida pela administração repetida de cocaína em micos-estrela. 2011. 81 f., il. Dissertação (Mestrado em Ciências da Saúde)—Universidade de Brasília, Brasília, 2011.
Abstract:	Repeated exposure to the pyschostimulant cocaine induces a variety of effects, including behavioral sensitization. This is the increased expression of certain behaviors after the repeated administration of some drugs of abuse. In addition, the family of tachykinin neuropeptides seems to exert a modulatory role on the neural systems involved in addiction. Most studies, however, have analyzed this effect after the acute administration of NK3 receptor ligands in rodents. Thus, the present study evaluated in a non-human primate (black-tufted ear marmosets; Callithrix penicillata) the: 1) development of a behavioral sensitization effect after a repeated administration of cocaine; 2) effect of repeated activation of the NK3 receptor, with the direct agonist senktide, on behavioral changes induced by cocaine; and 3) cortisol levels before and after repeated injections of cocaine and senktide. Accordingly, 15 marmosets were divided into three groups (n=5) and subjected, during seven consecutive days, to a daily administration with saline, cocaine (7 mg/kg) or senktide (0.2 mg/kg). After each injection, behavioral observations were made during 20 min in an open field (OF) (treatment sessions, days 1-7). After seven days without any intervention, all animals received a single 5 mg/kg dose of cocaine and were again observed in the OF for 20 min (test session, day 14). A blood sample was obtained from each marmoset on days 0, 8, 15 and 30. A significant increase in vigilance behaviors was observed only in animals repeatedly treated with cocaine (7 mg/kg). This effect was maintained even after the administration of a lower dose of the drug (5 mg/kg) held after the seven-day withdrawal. Furthermore, treatment with senktide significantly increased glance levels and average speed when 5 mg/kg of cocaine was administered. On the other hand, cortisol levels remained unaltered throughout the study, regardless of the treatment given. Therefore, repeated treatment with cocaine induced a hypervigilance effect in the marmosets, which were sensitized by the present administration regimen. Also, repeated activation of the NK3 receptor with senktide potentiated some of the effects of 5 mg/kg of cocaine. Thus, the black-tufted ear marmoset seems to be a good experimental model, and the repeated and fixeddose protocol a unique tool, for comparative studies related to cocaine addiction. hypervigilance, cortisol.
metadata.dc.description.unidade:	Faculdade de Ciências da Saúde (FS)
Descripción :	Dissertação (mestrado)—Universidade de Brasília, Programa de Pós-graduação em Ciências da Saúde, 2011.
metadata.dc.description.ppg:	Programa de Pós-Graduação em Ciências da Saúde
Aparece en las colecciones:	Teses, dissertações e produtos pós-doutorado

Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.