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dc.contributor.authorOliveira, Gabriel de Sousa-
dc.contributor.authorLima, Ana Luiza-
dc.contributor.authorGranados Muñoz, Pedro-
dc.contributor.authorGross, Idejan Padilha-
dc.contributor.authorBarreto, Livia Cristina Lira de Sá-
dc.contributor.authorSouza, Patrícia Medeiros de-
dc.contributor.authorGratieri, Taís-
dc.contributor.authorGelfuso, Guilherme Martins-
dc.contributor.authorCunha Filho, Marcílio Sérgio Soares da-
dc.date.accessioned2026-10-22T13:38:43Z-
dc.date.available2026-10-22T13:38:43Z-
dc.date.issued2026-09-21-
dc.identifier.citationOLIVEIRA, Gabriel S. et al. Beyond immediate release: FDM‑printed pediatric 6‑Mercaptopurine chewable tablets with spontaneous In situ nanostructure formation. AAPS PharmSciTech, v. 27, art. n. 302, 2026. DOI: https://doi.org/10.1208/s12249-026-03556-7. Disponível em: https://link.springer.com/article/10.1208/s12249-026-03556-7. Acesso em: 22 out. 2026.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/57309-
dc.language.isoengpt_BR
dc.publisherSpringerpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleBeyond immediate release : FDM‑printed pediatric 6‑Mercaptopurine chewable tablets with spontaneous In situ nanostructure formationpt_BR
dc.typeArtigopt_BR
dc.subject.keyword6-Mercaptopurinapt_BR
dc.subject.keywordImpressão 3Dpt_BR
dc.subject.keywordMedicamentospt_BR
dc.subject.keywordFormulações pediátricaspt_BR
dc.subject.keywordLeucemia linfoblástica agudapt_BR
dc.subject.keywordSistemas de liberação de fármacospt_BR
dc.rights.licenseOpen Access This article is licensed under a Creative Commons Attri bution 4.0 International License, which permits use, sharing, adapta tion, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.pt_BR
dc.description.abstract1Pediatric maintenance therapy for acute lymphoblastic leukemia requires prolonged daily administration of 6-mercaptopurine (6-MP), a drug characterized by a narrow therapeutic index and substantial interindividual variability, creating a need for flexible and patient-friendly dosage forms. This study aimed to develop pediatric chewable tablets 6-MP using hot-melt extrusion and fused deposition modeling (FDM) 3D printing. Preformulation studies and rheological characterization were performed to support formulation development. The influence of internal architecture on porosity, disintegration, mechanical properties, and chewability was investigated by varying infill density. Among the evaluated architectures, 30% infill provided the best balance between structural integrity, porosity, rapid disintegration, and softening after saliva exposure, ensuring adequate chewability. Tablets exhibited accurate drug content (99.5 ± 2.2%). Beyond their immediate-release behavior, complete drug release was achieved within 15 min, while colloidal nanostructures were spontaneously formed, associating approximately 11% of dissolved 6-MP, suggesting a hybrid release mechanism combining rapid drug availability with nano-mediated modulation. Dynamic light scattering and transmission electron microscopy confirmed these findings. Overall, the developed platform demonstrates the potential of FDM-based structural engineering to produce personalized pediatric medicines and reveals that thermally processed polymeric matrices may function as dynamic drug delivery systems rather than conventional immediate-release dosage forms.pt_BR
dc.identifier.orcidhttps://orcid.org/0009-0005-7175-164Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2177-8941pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9787-7076pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1798-7927pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8197-4349pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4022-9187pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6481-2364pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1924-7885pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9167-6852pt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Food, Drugs, and Cosmeticspt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Food, Drugs, and Cosmeticspt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Food, Drugs, and Cosmeticspt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Food, Drugs, and Cosmeticspt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Ceilandiapt_BR
dc.contributor.affiliationUniversity of Brasilia, School of Health Sciencespt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Food, Drugs, and Cosmeticspt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Food, Drugs, and Cosmeticspt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Food, Drugs, and Cosmeticspt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Farmácia (FS FAR)pt_BR
dc.description.unidadeFaculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB Ceilândiapt_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências da Saúde-
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