| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Bispo, Elizabete Cristina Iseke | pt_BR |
| dc.contributor.author | Pontes, Cláudia de Souza Lima | pt_BR |
| dc.contributor.author | Nascimento, Jennifer Martins do | pt_BR |
| dc.contributor.author | Alves, Fábio Wilson de Lima | pt_BR |
| dc.contributor.author | Carvalho, Juliana Lott de | pt_BR |
| dc.contributor.author | Araujo, Antônio Roberto Lucena | pt_BR |
| dc.contributor.author | Araujo, Felipe Saldanha | pt_BR |
| dc.date.accessioned | 2026-08-12T16:00:34Z | - |
| dc.date.available | 2026-08-12T16:00:34Z | - |
| dc.date.issued | 2026-7 | pt_BR |
| dc.identifier.citation | BISPO, Elizabete Cristina Iseke; PONTES, Cláudia de Souza Lima; NASCIMENTO, Jennifer Martins do; ALVES, Fábio Wilson de Lima; CARVALHO, Juliana Lott de; ARAUJO, Antônio Roberto Lucena; ARAUJO, Felipe Saldanha. Integrative transcriptomic and functional analysis of pkmyt1 reveals a potential therapeutic target in chronic lymphocytic leukemia. Hematological Oncology, v. 44, n. 4, 2026. DOI: https://doi.org/10.1002/hon.70208. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/hon.70208. Acesso em: 12 ago. 2026. | pt_BR |
| dc.identifier.uri | https://doi.org/10.1002/hon.70208 | pt_BR |
| dc.identifier.uri | http://repositorio.unb.br/handle/10482/55640 | - |
| dc.language.iso | eng | pt_BR |
| dc.publisher | Wiley | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Integrative transcriptomic and functional analysis of pkmyt1 reveals a potential therapeutic target in chronic lymphocytic leukemia | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Leucemia linfocítica crônica (LLC) | pt_BR |
| dc.subject.keyword | Instabilidade genômica | pt_BR |
| dc.subject.keyword | Regulação do ciclo celular | pt_BR |
| dc.rights.license | This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the
original work is properly cited. | pt_BR |
| dc.identifier.doi | https://doi.org/10.1002/hon.70208 | pt_BR |
| dc.description.abstract1 | Chronic lymphocytic leukemia (CLL) is a clinically and molecularly heterogeneous disease. PKMYT1, a G2/M cell cycle kinase, has been implicated in tumor progression in several cancers, but its role in CLL remains unclear. We evaluated
PKMYT1
expression in primary CLL samples and analyzed associations with cytogenetic features and clinical parameters.
PKMYT1
expression was heterogeneous and correlated with adverse features, including complex karyotype and elevated leukocyte counts. Comparative transcriptomic analyses between high‐ and low‐expression groups revealed enrichment of pathways related to chromatin remodeling, DNA repair, and mitotic regulation. In MEC1 cells, pharmacological PKMYT1 inhibition significantly reduced cancer cell viability. PCR analysis showed upregulation of
TP53, CASP3, BAK, GSDMD, BCL2, CASP1, IL1β, RIPK1, and RIPK3
, indicating activation of apoptotic, inflammasome‐associated, and necroptotic pathways. Collectively, these findings demonstrate that
PKMYT1
is heterogeneously expressed in CLL, associated with adverse cytogenetic and clinical features, and critical for cell survival, highlighting its potential as a therapeutic target. | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-4200-0821 | pt_BR |
| dc.contributor.affiliation | Universidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Hematologia e Células‐Tronco | pt_BR |
| dc.contributor.affiliation | Universidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Hematologia e Células‐Tronco | pt_BR |
| dc.contributor.affiliation | Universidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Hematologia e Células‐Tronco | pt_BR |
| dc.contributor.affiliation | Universidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Hematologia e Células‐Tronco | pt_BR |
| dc.contributor.affiliation | Universidade de Brasília, Faculdade de Medicina, Laboratório de Biociências | pt_BR |
| dc.contributor.affiliation | Universidade Federal de Pernambuco, Centro de Biociências, Laboratório de Hematologia | pt_BR |
| dc.contributor.affiliation | Universidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Hematologia e Células‐Tronco | pt_BR |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
|
