Título:	Hepatoprotective potential of some species of Erythroxylum, Eugenia and Pouteria genera from Brazilian savanna against acetaminophen-induced liver injury
Autor(es):	Leão, Mayra Cardoso Couto Fagg, Christopher William Simeoni, Luiz Alberto Homem de Mello, Mauricio Magalhães, Pérola Oliveira Silveira, Damaris Bazzo, Yris Maria Fonseca
ORCID:	https://orcid.org/0000-0001-6072-7832 https://orcid.org/0000-0003-3401-290X https://orcid.org/0000-0002-4541-9177 https://orcid.org/0000-0001-8011-6940 https://orcid.org/0000-0003-1851-5224 https://orcid.org/0000-0002-1230-3207
Afiliação do autor:	University of Brasília University of Brasília University of Brasília University of Brasília University of Brasília University of Brasília University of Brasília
Assunto:	Paracetamol Fitoterapia Atividade hepatoprotetora
Data de publicação:	Jul-2025
Editora:	SAGE Publications
Referência:	LEÃO, Mayra Cardoso Couto; FAGG, Christopher William; SIMEONI, Luiz Alberto; HOMEM-DE-MELLO, Mauricio; MAGALHÃES, Pérola Oliveira; SILVEIRA, Damaris; FONSECA-BAZZO, Yris Maria. Hepatoprotective potential of some species of Erythroxylum, Eugenia and Pouteria genera from Brazilian savanna against acetaminophen-induced liver injury. Natural Product Communications, [S. l.], v. 20, n. 7, 2025. DOI: https://doi.org/10.1177/1934578x251360959. Disponível em: https://journals.sagepub.com/doi/full/10.1177/1934578X251360959#con1. Acesso em: 30 jul. 2026.
Abstract:	Objectives Liver injury is a major global public health concern. Despite advancements in modern medicine, there remains a pressing need to identify more effective and less toxic therapeutic options for managing liver diseases. This study aimed to assess the hepatoprotective potential of Erythroxylum daphnites Mart., Erythroxylum suberosum A.St.-Hil., Eugenia dysenteria (Mart.) DC., Pouteria torta (Mart.) Radlk., and Pouteria ramiflora (Mart.) Radlk. against acetaminophen (APAP)-induced injury in human hepatocarcinoma (HepG2) cells. Methods The hepatoprotective potential of the extracts was evaluated in HepG2 cells using APAP as the injury-inducing agent. Additionally, the chemical composition of the extracts was analyzed using high-performance liquid chromatography coupled with diode-array detection (HPLC-DAD). Results Chemical analysis of the plant extracts revealed the presence of polyphenolic compounds, including flavonoids and phenolic acids. All tested extracts exhibited a significant protective effect against APAP-induced cell death in both pre-treatment and post-treatment protocols. Conclusion This study highlights the potential of natural products from the Cerrado biome as hepatoprotective agents. The observed protective effects are likely attributed to the diverse chemical compounds present in these extracts.
Unidade Acadêmica:	Faculdade de Ciências da Saúde (FS) Departamento de Farmácia (FS FAR)
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências Farmacêuticas
Licença:	(CC BY NC) Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub. com/en-us/nam/open-access-at-sage).
DOI:	https://doi.org/10.1177/1934578x251360959
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