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dc.contributor.authorSilva, Franklyn Santos dapt_BR
dc.contributor.authorMatos, Breno Noronhapt_BR
dc.contributor.authorSantos, Rebeca Dias dospt_BR
dc.contributor.authorAmaral, Venancio Alvespt_BR
dc.contributor.authorAraújo, Marta Oliveira dept_BR
dc.contributor.authordo Prado, Bruno Alcântarapt_BR
dc.contributor.authorMartins, Cinara Medeiropt_BR
dc.contributor.authorCamara, Claudio Augusto Gomes dapt_BR
dc.contributor.authorMoraes, Marcilio Martins dept_BR
dc.contributor.authorDias, Diego Juscelino Santospt_BR
dc.contributor.authorCardoso, Camila Oliveirapt_BR
dc.contributor.authorBarreto, Livia Cristina Lira de Sápt_BR
dc.contributor.authorSilva, Izabel Cristina Rodrigues dapt_BR
dc.contributor.authorOrsi, Daniela Castilhopt_BR
dc.contributor.authorGelfuso, Guilherme Martinspt_BR
dc.date.accessioned2026-07-30T12:38:31Z-
dc.date.available2026-07-30T12:38:31Z-
dc.date.issued2026-2-28pt_BR
dc.identifier.citationSILVA, Franklyn Santos da et al. Development of an antimicrobial nanoemulsion based on cordia verbenacea essential oil: properties, stability, irritability, and in vitro skin permeation. Pharmaceutics, [S. l.], v. 18, n. 3, 313, 2026. DOI: https://doi.org/10.3390/pharmaceutics18030313. Disponível em: https://www.mdpi.com/1999-4923/18/3/313. Acesso em: 30 jul. 2026.pt_BR
dc.identifier.urihttps://doi.org/10.3390/pharmaceutics18030313pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/55540-
dc.language.isoengpt_BR
dc.publisherMDPI AGpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleDevelopment of an antimicrobial nanoemulsion based on cordia verbenacea essential oil: properties, stability, irritability, and in vitro skin permeationpt_BR
dc.typeArtigopt_BR
dc.rights.licenseThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.pt_BR
dc.identifier.doihttps://doi.org/10.3390/pharmaceutics18030313pt_BR
dc.description.abstract1Background/Objectives: This study aimed to evaluate the chemical composition and antimicrobial activity of Cordia verbenacea essential oil (EOCV) and to develop and characterize a gel-based nanoemulsion of C. verbenacea essential oil (NECV). Methods: The EOCV was chemically characterized by gas chromatography (GC-FID and GC-MS). The nanoemulsion was prepared using EOCV, the surfactants Cremophor and Plurol Oleique, and phosphate buffer at pH 5.5, and was subjected to experiments to determine its stability, irritant potential and in vitro skin permeation. Results: The main chemical compounds identified in EOCV were α-pinene (33.05%) and β-caryophyllene (25.11%). The EOCV exhibited antimicrobial activity with MIC and MBC values ranging from 6.3 to 25.0 µL/mL for the yeasts Candida albicans and C. krusei, 11.3 to 25.0 µL/mL for the Gram-positive bacteria Bacillus cereus, Staphylococcus aureus, and Enterococcus faecalis, and 12.5 to 75.0 µL/mL for the Gram-negative bacteria Acinetobacter baumannii, Klebsiella pneumoniae, and Escherichia coli. The NECV showed a droplet size of 126.80 nm, a polydispersity index (PDI) of 0.49, a zeta potential of −18.50 mV and a pH of 5.3 and remained stable for 60 days of storage at 25 °C and 4 °C. The HET-CAM irritation test showed that the formulation is non-irritating. The in vitro skin permeation assay showed that the NECV penetrated the deeper layers of the skin, demonstrating its ability to overcome the Stratum corneum barrier. Conclusions: These results are highly promising regarding the potential use of NECV for topical application for the treatment of infected skin wounds.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4052-2618pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3560-3755pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8508-1230pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6836-3583pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7325-9871pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1924-7885pt_BR
dc.contributor.affiliationUniversity of Brasília (UNB/FCE), Laboratory of Quality Controlpt_BR
dc.contributor.affiliationUniversity of Brasília (UNB/FS), Laboratory of Food, Drugs, and Cosmeticspt_BR
dc.contributor.affiliationUniversity of Brasília (UNB/FS), Laboratory of Food, Drugs, and Cosmeticspt_BR
dc.contributor.affiliationUniversity of Brasília (UNB/FCE), Laboratory of Quality Controlpt_BR
dc.contributor.affiliationUniversity of Brasília (UNB/FS), Laboratory of Food, Drugs, and Cosmeticspt_BR
dc.contributor.affiliationUniversity of Brasília (UNB/FS), Laboratory of Food, Drugs, and Cosmeticspt_BR
dc.contributor.affiliationUniversity of Brasília (UNB/FCE), Laboratory of Quality Controlpt_BR
dc.contributor.affiliationUniversity of Brasília (UNB/FCE), Laboratory of Quality Controlpt_BR
dc.contributor.affiliationUniversity of Brasília (UNB/FS), Laboratory of Food, Drugs, and Cosmeticspt_BR
dc.contributor.affiliationUniversity of Brasília (UNB/FCE), Laboratory of Quality Controlpt_BR
dc.contributor.affiliationFederal Rural University of Pernambuco,Laboratory of Bioactive Natural Products, Department of Chemistrypt_BR
dc.contributor.affiliationFederal Rural University of Pernambuco, Laboratory of Bioactive Natural Products, Department of Chemistrypt_BR
dc.contributor.affiliationUniversity of Brasília (UNB/FCE), Laboratory of Quality Controlpt_BR
dc.contributor.affiliationUniversity of Brasília (UNB/FS), Laboratory of Food, Drugs, and Cosmeticspt_BR
dc.contributor.affiliationUniversity of Brasília (UNB/FS), Laboratory of Food, Drugs, and Cosmeticspt_BR
dc.contributor.affiliationUniversity of Brasília (UNB/FCE), Laboratory of Quality Controlpt_BR
dc.contributor.affiliationUniversity of Brasília (UNB/FCE), Laboratory of Quality Controlpt_BR
dc.contributor.affiliationUniversity of Brasília (UNB/FS), Laboratory of Food, Drugs, and Cosmeticspt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Farmácia (FS FAR)pt_BR
dc.description.unidadeFaculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB Ceilândiapt_BR
dc.description.unidadeCurso de Farmácia (FCTS-FAR)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências Farmacêuticas-
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