Título:	The changes on salivary flow rates, buffering capacity and chromogranin a levels in adults after bariatric surgery
Autor(es):	Kogawa, Evelyn Mikaela Melo, Fabíola Ferreira Pires, Reuel Gomes Caetano, Paulo César Candeia Rodrigues, Jhonatan de Lima Benito, Linconl Agudo Oliveira Silva, Izabel Cristina Rodrigues da Cantuária, Ana Paula de Castro Peres, Silvia Helena Sales
Afiliação do autor:	Universidade de São Paulo, Faculdade de Odontologia de Bauru Universidade de Brasília, Faculdade de Ciências da Saúde, Departamento de Odontologia Universidade de Brasília, Programa de Pós-Graduação em Odontologia Universidade de Brasília, Programa de Pós-Graduação em Odontologia Universidade Católica de Brasília, Curso de Odontologia Universidade Católica de Brasília, Curso de Odontologia Universidade de Brasília, Pós-Graduação em Ciências e Tecnologias em Saúde Universidade de Brasília, Faculdade UnB Ceilândia Universidade de Brasília, Pós-Graduação em Ciências e Tecnologias em Saúde Universidade de São Paulo, Faculdade de Odontologia de Bauru
Assunto:	Cirurgia bariátrica Fluxo salivar Saliva Cromogranina A Odontologia ELISA (Ensaio de Imunoadsorção Enzimática)
Data de publicação:	21-fev-2024
Editora:	Springer Science and Business Media LLC
Referência:	KOGAWA, Evelyn Mikaela et al. The changes on salivary flow rates, buffering capacity and chromogranin a levels in adults after bariatric surgery. Clinical Oral Investigations, [S. l.], v. 28, n. 3, 159, 2024. DOI: https://doi.org/10.1007/s00784-024-05551-3. Disponível em: https://link.springer.com/article/10.1007/s00784-024-05551-3.
Abstract:	Objectives This study aimed to investigate changes in salivary flow rates, buffering capacity, and salivary chromogranin A (CHGA) levels in adults undergoing bariatric surgery (BS) compared with a non-obese control group. Materials and methods Salivary analyses were performed on 62 participants aged over 50 years, stratified into two groups matched for age and gender—individuals who had undergone bariatric surgery (BS) (n = 31) and a corresponding healthy control group (n = 31). Before saliva collection, participants completed a comprehensive 11-point visual numerical rating scale (NRS 0–10) xerostomia questionnaire, assessing subjective perceptions of two key aspects: dryness of the oral mucosa and resultant impact on oral functional ability. Three distinct saliva measurements were obtained: unstimulated whole saliva (UWS), stimulated whole saliva (SWS), and unstimulated upper labial saliva (ULS). The buffering capacity of unstimulated saliva was assessed using pH indicator strips, and concentrations of salivary Chromogranin A (CHGA) were quantified in stimulated saliva via enzyme-linked immunosorbent assay (ELISA). Results After BS, more than 40% of BS group patients reported xerostomia, with 16.1% experiencing only mild symptoms without significant functional impact (p = 0.009). The prevalence of xerostomia and tongue dryness was higher in the BS group compared to the control group (p = 0.028 and p = 0.025, respectively). The comparative analysis unveiled no statistically significant differences in flow rates of unstimulated upper labial saliva (ULS), unstimulated whole saliva (UWS), and stimulated whole saliva (SWS) between the control group and patients who underwent bariatric surgery. However, in patients undergone BS with xerostomia, both ULS and UWS flow rates were significantly lower than in controls with xerostomia (p = 0.014 and p = 0.007, respectively). The buffering capacity was significantly lower in patients undergone BS than in controls (p = 0.009). No differences were found between groups regarding CHGA concentration and output values, nevertheless, higher values of CHGA concentrations were significantly correlated to lower flow rates. Conclusion According to the results, this study suggests that individuals undergoing BS may exhibit altered salivary buffering capacity and reduced unstimulated salivary flows in the presence of xerostomia. Additionally, the findings suggest that elevated concentration of salivary CHGA might be associated, in part, with salivary gland hypofunction.
Unidade Acadêmica:	Faculdade de Ciências da Saúde (FS) Departamento de Odontologia (FS ODT) Faculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB Ceilândia
Programa de pós-graduação:	Programa de Pós-Graduação em Odontologia Pós-Graduação em Ciências e Tecnologias em Saúde
DOI:	https://doi.org/10.1007/s00784-024-05551-3
Versão da editora:	https://link.springer.com/article/10.1007/s00784-024-05551-3
Aparece nas coleções:	Artigos publicados em periódicos e afins

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