Título:	Variante genética DRD2 TaqIA em pacientes com transtorno depressivo maior
Autor(es):	Possatti, Isabella
Orientador(es):	Silva, Izabel Cristina Rodrigues da
Assunto:	Transtorno depressivo maior Polimorfismo genético Revisão sistemática
Data de publicação:	29-Jun-2026
Data de defesa:	31-Jul-2023
Referência:	POSSATTI, Isabella. Variante genética DRD2 TaqIA em pacientes com transtorno depressivo maior. 2023. 145 f., il. Dissertação (Mestrado em Ciências e Tecnologias em Saúde) — Universidade de Brasília, Brasília, 2023.
Abstract:	Major Depressive Disorder (MDD) is a disabling illness that affects millions of people every year and has as characteristic symptoms the lack of pleasure in carrying out daily activities and depressed mood for a period of 2 weeks or more. Depression is a multifactorial disease, that is, it does not have a specific cause. However, because dopamine plays an important role in the motivation and reward process when it binds to its D2 receptor, it becomes a fundamental component of the pathophysiology of MDD. This receptor is encoded by the DRD2 gene, which is located on chromosome 11q22.23 and has a well-studied variant, TaqIA, a single nucleotide polymorphism, where a nitrogenous base is exchanged, in this case, a cytosine for a thymine, consequently leading to a decrease in the bioavailability of dopamine D2 receptors. Therefore, the aim of this study is to verify whether the DRD2TaqIA polymorphism is associated with Major Depressive Disorder through a scientific production in the form of a systematic review and based on molecular and biochemical analyses. The systematic review carried out followed the PECOS methodology to define the inclusion and exclusion criteria for the papers. The search was carried out in 4 databases: PubMed, Web Of Science, Scopus and Virtual Health Library. Afterwards, the works were evaluated more specifically by the Rayyan tool and finally a table was created with the articles included. Molecular analyzes were performed from biological samples collected from patients with MDD who are followed up at the Psychosocial Care Center III, located in Samambaia Sul. The genotyping of the samples was performed using the DNA extraction and the Polymerase Chain Reaction technique and the digestion of the samples using the TaqI restriction enzyme. The systematic review resulted in five selected articles and in two of them there was an association of the DRD2TaqIA variant with MDD and depressive symptoms, with the A1(T) allele being more present in the Chinese and American populations and the A2(C) allele more present in the Russian population. Through molecular analysis, there was no statistical significance between the polymorphism and the biochemical tests performed. The systematic review revealed that the frequency of genotypes and alleles varies according to the studied population and the molecular analysis showed that the genetic variant does not influence the biochemical tests in patients with major depressive disorder.
Unidade Acadêmica:	Faculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB Ceilândia
Informações adicionais:	Dissertação (mestrado) — Universidade de Brasília, Faculdade de Ceilândia, Programa de Pós-Graduação em Ciências e Tecnologias em Saúde, 2023.
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências e Tecnologias em Saúde
Agência financiadora:	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Aparece nas coleções:	Teses, dissertações e produtos pós-doutorado

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