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dc.contributor.authorScalon, Marcela Corrêapt_BR
dc.contributor.authorMartins, Christine Souzapt_BR
dc.contributor.authorFerreira, Gabriel Ginanipt_BR
dc.contributor.authorSchlemmer, Francielept_BR
dc.contributor.authorAlmeida, Ricardo Titze dept_BR
dc.contributor.authorPaludo, Giane Reginapt_BR
dc.date.accessioned2026-06-11T21:19:20Z-
dc.date.available2026-06-11T21:19:20Z-
dc.date.issued2022-12-20pt_BR
dc.identifier.citationSCALON, Marcela Correa; MARTINS, Christine Souza; FERREIRA, Gabriel Ginani; SCHLEMMER, Franciele; ALMEIDA, Ricardo Titze de; PALUDO, Giane Regina. MiR-20a is upregulated in serum from domestic feline with PKD1 mutation. PLOS ONE, San Francisco, v. 17, n. 12, p. e0279337, 2022. DOI https://doi.org/10.1371/journal.pone.0279337. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0279337. Acesso em: 11 jun. 2026.pt_BR
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0279337pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/54774-
dc.language.isoengpt_BR
dc.language.isoporpt_BR
dc.publisherPublic Library of Science (PLoS)pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleMiR-20a is upregulated in serum from domestic feline with PKD1 mutationpt_BR
dc.typeArtigopt_BR
dc.subject.keywordGato - doençaspt_BR
dc.subject.keywordAnimais domésticos - doençaspt_BR
dc.subject.keywordPlasmapt_BR
dc.subject.keywordDoença renal policísticapt_BR
dc.rights.licenseThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FONTE: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0279337. Acesso em: 11 jun. 2026.pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0279337pt_BR
dc.description.abstract1Polycystic kidney disease (PKD), also known as autosomal dominant polycystic kidney disease (ADPKD) is a genetically heterogeneous condition characterized by cysts in renal parenchyma. It is the most prevalent inherited disease of domestic cats. MicroRNAs (miRNAs or ncRNA) are short, noncoding, single-stranded RNAs that may induce PKD cytogenesis by affecting numerous targets genes as well as by directly regulating PKD gene expression. We compared the relative expression profile of miR-20a, -192, -365, -15b-5p, and -16-5p from plasma and serum samples of nine domestic cats with PKD1 mutation, detected by polymerase chain reaction (PCR), and a control group (n = 10). Blood samples from cats with PKD1 mutation provide similar concentrations of microRNAs either from plasma or serum. Serum miR-20a is upregulated in PKD group with p < 0.005; Roc curve analysis showed an AUC of 90,1% with a cut-off value sensitivity of 77.8% and specificity of 100%. This data provides important information regarding renal miRNA expression in peripheral blood sampling.en
dc.identifier.orcidhttps://orcid.org/0000-0002-9112-1718pt_BR
dc.contributor.affiliationUniversity of Brasília, College of Agronomy and Veterinary Medicine, Veterinary Clinical Pathology Laboratorypt_BR
dc.contributor.affiliationUniversity of Brasília, College of Agronomy and Veterinary Medicine, Veterinary Clinical Pathology Laboratorypt_BR
dc.contributor.affiliationUniversity of Brasília, College of Agronomy and Veterinary Medicine, Technology for Gene Therapy Laboratorypt_BR
dc.contributor.affiliationUniversity of Brasília, College of Agronomy and Veterinary Medicine, Technology for Gene Therapy Laboratorypt_BR
dc.contributor.affiliationUniversity of Brasília, College of Agronomy and Veterinary Medicine, Technology for Gene Therapy Laboratorypt_BR
dc.contributor.affiliationUniversity of Brasília, College of Agronomy and Veterinary Medicine, Veterinary Clinical Pathology Laboratorypt_BR
dc.description.unidadeFaculdade de Agronomia e Medicina Veterinária (FAV)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências Animaispt_BR
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