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dc.contributor.authorQuintanilha, Maria Varela Torres-
dc.contributor.authorGobbo, Giovanna de Azevedo Mello-
dc.contributor.authorPinheiro, Gabriela Beserra-
dc.contributor.authorSouza, Adolfo Carlos Barros de-
dc.contributor.authorCamargo, Luana Cristina-
dc.contributor.authorMortari, Marcia Renata-
dc.date.accessioned2026-05-08T12:28:42Z-
dc.date.available2026-05-08T12:28:42Z-
dc.date.issued2024-08-
dc.identifier.citationQUINTANILHA, Maria Varela Torres et al. Evaluating a venom-bioinspired peptide, NOR-1202, as an antiepileptic treatment in male mice models. Toxins, [S. l.], v. 16, n. 8, 342, 2024. DOI: https://doi.org/10.3390/toxins16080342. Disponível em: https://www.mdpi.com/2072-6651/16/8/342. Acesso em: 4 mai. 2026.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/54341-
dc.language.isoengpt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleEvaluating a venom-bioinspired peptide, NOR-1202, as an antiepileptic treatment in male mice modelspt_BR
dc.typeArtigopt_BR
dc.subject.keywordEpilepsia do lobo temporal (ELT)pt_BR
dc.subject.keywordAntiepilépticospt_BR
dc.subject.keywordOccidentalina-1202pt_BR
dc.subject.keywordPilocarpinapt_BR
dc.subject.keywordÁcido caínicopt_BR
dc.subject.keywordVespa - venenopt_BR
dc.rights.license© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).pt_BR
dc.identifier.doihttps://doi.org/10.3390/toxins16080342pt_BR
dc.description.abstract1Epilepsy, a neurological disorder characterized by excessive neuronal activity and synchronized electrical discharges, ranks among the most prevalent global neurological conditions. Despite common use, antiepileptic drugs often result in adverse effects and lack effectiveness in controlling seizures in temporal lobe epilepsy (TLE) patients. Recent research explored the potential of occidentalin-1202, a peptide inspired by Polybia occidentalis venom, in safeguarding Wistar rats from chemically induced seizures. The present study evaluated the new analog from occidentalin-1202 named NOR-1202 using acute and chronic pilocarpine-induced models and an acute kainic acid (KA) male mice model. NOR-1202 was administered through the intracerebroventricular (i.c.v.), subcutaneous, or intraperitoneal routes, with stereotaxic procedures for the i.c.v. injection. In the acute pilocarpine-induced model, NOR-1202 (i.c.v.) protected against generalized seizures and mortality but lacked systemic antiepileptic activity. In the KA model, it did not prevent generalized seizures but improved survival. In the chronic TLE model, NOR-1202′s ED50 did not differ significantly from the epileptic or healthy groups regarding time spent in spontaneous recurrent seizures during the five-day treatment. However, the NOR-1202 group exhibited more seizures than the healthy group on the second day of treatment. In summary, NOR-1202 exhibits antiepileptic effects against chemoconvulsant-induced seizures, but no effect was observed when administered systemically.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7223-037Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6849-6001pt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacologypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacologypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacologypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacologypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacologypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacologypt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)pt_BR
dc.description.unidadeDepartamento de Ciências Fisiológicas (IB CFS)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Biologia Animalpt_BR
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