Selective Ru(II)/benzoate complexes against triple-negative breast tumor cells and their interactions with DNA and BSA

Teixeira, Tamara; Ribeiro, Gabriel H.; Gonçalves, Guilherme R.; Araújo Neto, João Honorato de; Oliveira, Katia Mara de; Correa, Rodrigo S.

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Élément Dublin Core	Valeur	Langue
dc.contributor.author	Teixeira, Tamara	-
dc.contributor.author	Ribeiro, Gabriel H.	-
dc.contributor.author	Gonçalves, Guilherme R.	-
dc.contributor.author	Araújo Neto, João Honorato de	-
dc.contributor.author	Oliveira, Katia Mara de	-
dc.contributor.author	Correa, Rodrigo S.	-
dc.date.accessioned	2025-03-13T21:18:33Z	-
dc.date.available	2025-03-13T21:18:33Z	-
dc.date.issued	2024-04-22	-
dc.identifier.citation	TEIXEIRA, Tamara et. al. Selective Ru(II)/benzoate complexes against triple-negative breast tumor cells and their interactions with DNA and BSA. Inorganica Chimica Acta, v. 568, art. 122078, 1 ago. 2024. DOI 10.1016/j.ica.2024.122078. Disponível em: https://www.sciencedirect.com/science/article/pii/S0020169324001683?via%3Dihub. Acesso em: 13 mar. 2025.	pt_BR
dc.identifier.uri	http://repositorio.unb.br/handle/10482/51884	-
dc.language.iso	eng	pt_BR
dc.publisher	Elsevier	pt_BR
dc.rights	Acesso Restrito	pt_BR
dc.title	Selective Ru(II)/benzoate complexes against triple-negative breast tumor cells and their interactions with DNA and BSA	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Rutênio	pt_BR
dc.subject.keyword	Elementos químicos - atividade citotóxica	pt_BR
dc.subject.keyword	Mamas - câncer - tratamento	pt_BR
dc.rights.license	© 2024 Elsevier B.V. All rights reserved.	pt_BR
dc.identifier.doi	https://doi.org/10.1016/j.ica.2024.122078	pt_BR
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S0020169324001683?via%3Dihub	pt_BR
dc.description.abstract1	New ruthenium(II) complexes bearing benzoate (AB) ligand with the general formula [Ru(AB)(bipy)(P–P)]PF6, where 2,2′-bipyridine (bipy) and different diphosphine ligands, (P–P) = 1,2′-bis(diphenylphosphine)ethane(dppe, 1), 1,3′-bis(diphenylphosphine)propane (dppp, 2) and 1,2′-bis(diphenylphosphine)ferrocene (dppf, 3), were synthesized. The compounds were characterized by molar conductivity, elemental analysis, cyclic voltammetry, infrared and UV–Vis spectroscopies, NMR, and by single-crystal X-ray diffraction for complexes 1 and 2. The complexes showed a weak interaction to CT-DNA through DNA minor groove, with Kb values at around 103-104 M− 1. CT-DNA interaction assays by viscosity and circular dichroism (CD) suggested that the compounds do not significantly alter the secondary DNA structure. The complexes are cytotoxic against MDA-MB-231, MCF7 (breast) and A549 (lung) tumor cell lines, with IC50 values in the range of 1 to 17 µM. The compounds 1-3 showed high selectivity against triple-negative breast tumor cells. Remarkably, complexes 1 and 3 show greater cytotoxic activity against cells than cisplatin, being promising agents for tumor treatment.	pt_BR
dc.identifier.orcid	https://orcid.org/0000-0002-1127-6083	pt_BR
dc.identifier.orcid	https://orcid.org/0000-0003-4749-0281	pt_BR
dc.contributor.email	mailto:tamarateixeira@estudante.ufscar.br	pt_BR
dc.contributor.affiliation	Chemistry Department, ICEB, Federal University of Ouro Preto – UFOP	pt_BR
dc.contributor.affiliation	Embrapa	pt_BR
dc.contributor.affiliation	Chemistry Department, ICEB, Federal University of Ouro Preto – UFOP	pt_BR
dc.contributor.affiliation	Physics Institute of São Carlos, University of São Paulo – USP	pt_BR
dc.contributor.affiliation	Universidade de Brasília	pt_BR
dc.contributor.affiliation	https://orcid.org/0000-0003-2783-0816	pt_BR
dc.description.unidade	Instituto de Química	pt_BR
Collection(s) :	Artigos publicados em periódicos e afins