| Élément Dublin Core | Valeur | Langue |
|---|
| dc.contributor.author | Pires, Felipe Queiroz | - |
| dc.contributor.author | Gross, Idejan Padilha | - |
| dc.contributor.author | Barreto, Livia Cristina Lira de Sá | - |
| dc.contributor.author | Gratieri, Taís | - |
| dc.contributor.author | Gelfuso, Guilherme Martins | - |
| dc.contributor.author | Báo, Sônia Nair | - |
| dc.contributor.author | Cunha Filho, Marcílio Sérgio Soares da | - |
| dc.date.accessioned | 2024-02-01T15:21:57Z | - |
| dc.date.available | 2024-02-01T15:21:57Z | - |
| dc.date.issued | 2023-07-03 | - |
| dc.identifier.citation | PIRES, Felipe Q. et al. In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices. European Journal of Pharmaceutical Sciences, v. 188,106517, 1 set. 2023. DOI: https://doi.org/10.1016/j.ejps.2023.106517. Disponível em: https://www.sciencedirect.com/science/article/pii/S0928098723001471?via%3Dihub. Acesso em: 02 fev. 2024. | pt_BR |
| dc.identifier.uri | http://repositorio.unb.br/handle/10482/47633 | - |
| dc.language.iso | eng | pt_BR |
| dc.publisher | Elsevier B.V. | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Naringenina | pt_BR |
| dc.subject.keyword | Nanopartículas | pt_BR |
| dc.subject.keyword | Medicamentos | pt_BR |
| dc.rights.license | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | pt_BR |
| dc.identifier.doi | https://doi.org/10.1016/j.ejps.2023.106517 | pt_BR |
| dc.description.abstract1 | The in-situ formation of nanoparticles from polymer-based solid medicines, although previously described, has
been overlooked despite its potential to interfere with oral drug bioavailability. Such polymeric pharmaceuticals
are becoming increasingly common on the market and can become even more popular due to the dizzying
advance of 3D printing medicines. Hence, this work aimed to study this phenomenon during the dissolution of 3D
printed tablets produced with three different polymers, hydroxypropylmethylcellulose acetate succinate
(HPMCAS), polyvinyl alcohol (PVA), and Eudragit RL PO® (EUD RL) combined with plasticizers and the model
drug naringenin (NAR). The components’ interaction, dissolution behavior, and characteristics of the formed
particles were investigated employing thermal, spectroscopic, mechanical, and chromatographic assays. All the
systems generated stable spherical-shaped particles throughout 24 h, encapsulating over 25% of NAR. Results
suggest encapsulation efficiencies variations may depend on interactions between polymer-drug, drug-plasti cizer, and polymer-plasticizer, which formed stable nanoparticles even in the drug absence, as observed with the
HPMCAS and EUD RL formulations. Additionally, components solubility in the medium and previous formulation
treatments are also a decisive factor for nanoparticle formation. In particular, the treatment provided by hot-melt
extrusion and FDM 3D printing affected the dissolution efficiency enhancing the interaction between the com ponents, reverberating on particle size and particle formation kinetics mainly for HPMCAS and EUD RL. In
conclusion, the 3D printing process influences the in-situ formation of nanoparticles, which can directly affect
oral drug bioavailability and needs to be monitored. | pt_BR |
| dc.contributor.affiliation | University of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and Cosmetics | pt_BR |
| dc.contributor.affiliation | University of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and Cosmetics | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Faculty of Ceilandia | pt_BR |
| dc.contributor.affiliation | University of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and Cosmetics | pt_BR |
| dc.contributor.affiliation | University of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and Cosmetics | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Institute of Biological Sciences, Laboratório de Microscopia e Microanálise | pt_BR |
| dc.contributor.affiliation | University of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and Cosmetics | pt_BR |
| dc.description.unidade | Faculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB Ceilândia | pt_BR |
| dc.description.unidade | Curso de Farmácia (FCTS-FAR) | pt_BR |
| dc.description.unidade | Faculdade de Ciências da Saúde (FS) | pt_BR |
| dc.description.unidade | Departamento de Farmácia (FS FAR) | pt_BR |
| dc.description.unidade | Instituto de Ciências Biológicas (IB) | pt_BR |
| dc.description.unidade | Departamento de Biologia Celular (IB CEL) | pt_BR |
| Collection(s) : | Artigos publicados em periódicos e afins
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