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Title: Impact of polyphenols in phagocyte functions
Authors: Cunha, Leandro Rodrigues da
Muniz-Junqueira, Maria Imaculada
Borges, Tatiana Karla dos Santos
metadata.dc.identifier.orcid: 0000-0002-9006-4619 0000-0002-6813-6276
Assunto:: Polifenóis
Issue Date: 21-Aug-2019
Publisher: Dove Press
Citation: CUNHA, Leandro Rodrigues da; MUNIZ-JUNQUEIRA, Maria Imaculada; BORGES, Tatiana Karla dos Santos. Impact of polyphenols in phagocyte functions. Journal of Inflammation Research, [S.l.], v. 12, p. 205-217, 2019. DOI: Disponível em: Acesso em: 20 dez. 2021.
Abstract: Polyphenols are a broad group of substances with potential health benefits found in plant species. Several of these compounds are capable of influencing the activation of intracellular signaling pathways, such as NF-kB, MAPK and JAK-STAT, responsible for the production of various inflammatory mediators such as tumor necrosis factor α (TNF-α) and interleukin 1 beta (IL-1β) and 12 (IL-12), enzymes involved in the production of reactive species such as inducible nitric oxide synthase (iNOS) and superoxide dehydrogenase (SOD), as well as enzymes involved in the production of eicosanoids, such as cyclooxygenase (COX) and lipoxygenase (LO). There is increased interest in the use of polyphenol-rich foods because of their immunomodulatory effect; however, the mechanisms used during macrophage responses are extremely complex and little is known about the effects of polyphenols on these cells. As such, this review summarizes the current view of polyphenol influences on macrophages.
Licença:: © 2019 da Cunha et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (
Appears in Collections:FMD - Artigos publicados em periódicos e preprints

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