Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines

Silva, Ihatanderson Alves da; Lima, Ana Luiza; Gratieri, Taís; Gelfuso, Guilherme Martins; Barreto, Lívia Lira Sá; Cunha Filho, Marcílio Sérgio Soares da

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Campo DC	Valor	Lengua/Idioma
dc.contributor.author	Silva, Ihatanderson Alves da	-
dc.contributor.author	Lima, Ana Luiza	-
dc.contributor.author	Gratieri, Taís	-
dc.contributor.author	Gelfuso, Guilherme Martins	-
dc.contributor.author	Barreto, Lívia Lira Sá	-
dc.contributor.author	Cunha Filho, Marcílio Sérgio Soares da	-
dc.date.accessioned	2021-11-24T19:28:34Z	-
dc.date.available	2021-11-24T19:28:34Z	-
dc.date.issued	2021-09-20	-
dc.identifier.citation	SILVA, Ihatanderson A. et al. Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines.Journal of Pharmaceutical Analysis, 2021. DOI: https://doi.org/10.1016/j.jpha.2021.09.010.	pt_BR
dc.identifier.uri	https://repositorio.unb.br/handle/10482/42427	-
dc.language.iso	Inglês	pt_BR
dc.publisher	Elsevier B.V.	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.title	Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines	pt_BR
dc.type	Manuscrito	pt_BR
dc.subject.keyword	Impressão 3D	pt_BR
dc.subject.keyword	Preformulação	pt_BR
dc.subject.keyword	Extrusão termofusível	pt_BR
dc.subject.keyword	Análise térmica	pt_BR
dc.subject.keyword	Compatibilidade droga-polímero	pt_BR
dc.identifier.doi	https://doi.org/10.1016/j.jpha.2021.09.010	pt_BR
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S2095177921001118	pt_BR
dc.description.abstract1	One of the challenges for developing three-dimensional printed medicines is related to their stability due to the manufacturing conditions involving high temperatures. This work proposed a new protocol for preformulation studies simulating thermal processing and aging of the printed medicines, tested regarding their morphology and thermal, crystallographic, and spectroscopic profiles. Generally, despite the strong drug-polymer interactions observed, the chemical stability of the model drugs was preserved under such conditions. In fact, in the metoprolol and Soluplus® composition, the drug's solubilization in the polymer produced a delay in the drug decomposition, suggesting a protective effect of the matrix. Paracetamol and polyvinyl alcohol mixture, in turn, showed unmistakable signs of thermal instability and chemical decomposition, in addition to physical changes. In the presented context, establishing protocols that simulate processing and storage conditions may be decisive for obtaining stable pharmaceutical dosage forms using three-dimensional printing technology.	pt_BR
dc.description.unidade	Faculdade de Ciências da Saúde (FS)	pt_BR
dc.description.unidade	Departamento de Farmácia (FS FAR)	pt_BR
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