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Title: Enhanced il-6 and il-12b gene expression after SARS-CoV-2 infection in leprosy patients may increase the risk of neural damage
Authors: Morais Júnior, Gilberto Santos
Kurizky, Patricia Shu
Cerqueira, Selma Regina Penha Silva
Barroso, Daniel Holanda
Schulte, Heidi Luise
Albuquerque, Cleandro Pires de
Gois, Eliana Teles de
Espindola, Laila Salmen
Santana, Jaime Martins de
Bastos, Izabela Marques Dourado
Araújo, Carla Nunes de
Mota, Licia Maria Henrique da
Nóbrega, Otávio de Tolêdo
Gomes, Ciro Martins
Assunto:: Hanseníase
SARS-CoV-2
Covid-19
Issue Date: 2021
Publisher: American Society of Tropical Medicine and Hygiene
Citation: MORAIS JUNIOR, Gilberto Santos et al. Enhanced il-6 and il-12b gene expression after SARS-CoV-2 infection in leprosy patients may increase the risk of neural damage. The American Journal of Tropical Medicine and Hygiene, Ahead of Print, p. 1-5, 2021. DOI: https://doi.org/10.4269/ajtmh.21-0034. Disponível em: https://www.ajtmh.org/view/journals/tpmd/aop/article-10.4269-ajtmh.21-0034/article-10.4269-ajtmh.21-0034.xml. Acesso em: 03 maio 2021.
Abstract: Experts have called attention to the possible negative impact of the coronavirus disease 2019 (COVID-19)–related cytokine storm syndrome on the progression of leprosy-related disabilities. We assessed the frequency of reactional states in patients co-infected with Mycobacterium leprae and severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 (SARS-CoV-2). We consecutively included patients during the first peak of the COVID-19 epidemic in Brazil and analyzed the expressions of genes encoding interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12A, IL-12B, and tumor necrosis factor-α in peripheral blood mononuclear cells. We included 64 leprosy patients and 50 controls. Twelve of the leprosy patients and 14 of the controls had been diagnosed with COVID-19. Co-infection was associated with increased IL-6 (P = 0.043) and IL-12B (P = 0.017) expression. The median disability grades were higher for leprosy/COVID-19 patients; however, the difference was not significant (P = 0.194). Patients co-infected with M. leprae and SARS-CoV-2 may experience a higher-grade proinflammatory state.
Licença:: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited - (CC BY NC). Fonte: https://www.ajtmh.org/view/journals/tpmd/aop/article-10.4269-ajtmh.21-0034/article-10.4269-ajtmh.21-0034.xml. Acesso em: 04 maio 2021.
DOI: https://doi.org/10.4269/ajtmh.21-0034
metadata.dc.relation.isbasedon: https://repositorio.unb.br/handle/10482/41534
Appears in Collections:CEL - Artigos publicados em periódicos
FMD - Artigos publicados em periódicos e preprints
PPGCS - Artigos publicados em periódicos e preprints
UnB - Covid-19

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