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dc.contributor.authorCosta, Gabriella Gusmão Pereira dapt_BR
dc.contributor.authorSilva, Cristian Aldemar Gascapt_BR
dc.contributor.authorGomes, João Victor Dutrapt_BR
dc.contributor.authorTorres, Amanda Gomespt_BR
dc.contributor.authorSantos, Izulmé Rita Imaculadapt_BR
dc.contributor.authorAlmeida, Fabrício Tavares Cunha dept_BR
dc.contributor.authorFagg, Christopher Williampt_BR
dc.contributor.authorSimeoni, Luiz Albertopt_BR
dc.contributor.authorSilveira, Dâmarispt_BR
dc.contributor.authorGomes-Copeland, Kicia Karinne Pereirapt_BR
dc.date.accessioned2020-01-24T10:30:21Z-
dc.date.available2020-01-24T10:30:21Z-
dc.date.issued2019pt_BR
dc.identifier.citationCOSTA, Gabriella Gusmão Pereira da et al. Influence of in vitro micropropagation on lycorine biosynthesis and anticholinesterase activity in Hippeastrum goianum. Revista Brasileira de Farmacognosia, v. 29, n. 2, p. 262-265, 2019. DOI: https://doi.org/10.1016/j.bjp.2019.02.001. Disponível em: http://scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000200262. Acesso em: 23 jan.2020.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/36338-
dc.language.isoenpt_BR
dc.publisherSociedade Brasileira de Farmacognosiapt_BR
dc.rightsAcesso Abertopt_BR
dc.titleInfluence of in vitro micropropagation on lycorine biosynthesis and anticholinesterase activity in Hippeastrum goianumpt_BR
dc.typeArtigopt_BR
dc.subject.keywordAlcalóidespt_BR
dc.subject.keywordBiossíntesept_BR
dc.subject.keywordCromatografia a líquidopt_BR
dc.subject.keywordLicorinapt_BR
dc.subject.keywordEspectrometria de massa-
dc.rights.licenseThis is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).-
dc.identifier.doihttps://doi.org/10.1016/j.bjp.2019.02.001pt_BR
dc.description.abstract1Hippeastrum goianum (Ravenna) Meerow, Amaryllidaceae, is an endemic species from the Cerrado, Brazil; there are only few studies about its chemistry or biological activity. This study aimed to investigate the occurrence of lycorine in extracts from in vitro H. goianum plantlets, as well as evaluate a possible inhibition of acetylcholinesterase. The ethanol extract of plantlets produced by in vitro seed germination and micropropagation of bulblets was obtained from seedlings from in vitro germination, while the ethanol extract micropropagtion of bulblets was obtained from a subculture of those seedlings. The presence of lycorine was detected in only in the micropropagation of bulblets. The micropropagation of bulblets was more active than the plantlets produced by in vitro seed germination, with an IC50 of 114.8 ± 0.95 µg/ml and IC50 386.00 ± 0.97 µg/ml, respectively. These results showed that both in vitro germination and micropropagation of H. goianum can lead to the biosynthesis of lycorine. Moreover, the micropropagation led to improved anticholinesterase activity.-
dc.identifier.orcidhttp://orcid.org/0000-0002-3393-5609-
dc.identifier.orcidhttp://orcid.org/0000-0003-4392-4230-
dc.identifier.orcidhttp://orcid.org/0000-0001-6098-3852-
dc.identifier.orcidhttp://orcid.org/0000-0001-9599-4578-
dc.identifier.orcidhttp://orcid.org/0000-0002-1503-1497-
dc.identifier.orcidhttp://orcid.org/0000-0002-0531-7483-
dc.identifier.orcidhttp://orcid.org/0000-0001-6072-7832-
dc.identifier.orcidhttp://orcid.org/0000-0003-3401-290X-
dc.identifier.orcidhttp://orcid.org/0000-0003-1851-5224-
dc.identifier.orcidhttp://orcid.org/0000-0003-3539-2916-
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