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Title: Evaluation of the impact of serogroup C meningococcal disease vaccination program in Brazil and its regions : a population-based study, 2001-2013
Authors: Moraes, Camile de
Moraes, José Cássio de
Silva, Gabriela Drummond Marques da
Duarte, Elisabeth Carmen
Assunto:: Meningite
Issue Date: Apr-2017
Publisher: Instituto Oswaldo Cruz, Ministério da Saúde
Citation: MORAES, Camile de et al. Evaluation of the impact of serogroup C meningococcal disease vaccination program in Brazil and its regions: a population-based study, 2001-2013. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 112, n. 4, p. 237-246, abr. 2017. Disponível em: <>. Acesso em: 22 fev. 2018. doi:
Abstract: Background: meningococcal C conjugate (MenC) vaccine was introduced as part of the Brazilian National Immunisation Program in 2010 for children < 1 year of age. Objectives: the study objective was to evaluate the impact of this vaccination strategy. Methods: an observational, mixed ecological and analytical study was conducted, based on time series panel data from surveillance records (2001-2013). Findings: a total of 37,538 of meningococcal disease cases were recorded during the study period. Of these, 19,997 were attributed to serogroup C. A decrease in meningococcal disease serogroup C (MDC) incidence among children aged < 1 year [65.2%; 95% confidence interval (CI): 20.5-84.7%] and 1-4 years (46.9%; 95%CI: 14.6-79.1%) were found in the three years following vaccination introduction. Vaccination impact on the reduction of MDC incidence varied from 83.7% (95%CI: 51.1-100.0%) in the Midwest region to 56.7% (95%CI: 37.4-76.0%) in the Northeast region. Main conclusions: vaccination against MDC in Brazil had a positive impact on the population of children aged < 1 year, across all regions, and on the 1-4 year-old cohort. Nevertheless, in our view there is scope for improving the vaccination strategy adopted in Brazil.
Licença:: Memórias do Instituto Oswaldo Cruz - This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). Fonte: Acesso em: 22 fev. 2018.
Appears in Collections:FMD - Artigos publicados em periódicos e preprints

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