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Title: Biopharmaceuticals from microorganisms : from production to purification
Authors: Jozala, Angela Faustino
Geraldes, Danilo Costa
Tundisi, Louise Lacalendola
Feitosa, Valker de Araújo
Breyer, Carlos Alexandre
Cardoso, Samuel Leite
Mazzola, Priscila Gava
Oliveira-Nascimento, Laura de
Rangel-Yagui, Carlota de Oliveira
Magalhães, Pérola de Oliveira
Oliveira, Marcos Antonio de
Pessoa Jr, Adalberto
Assunto:: Biofármacos
Processo - fermentação
Issue Date: Dec-2016
Publisher: Sociedade Brasileira de Microbiologia
Citation: JOZALA, Angela Faustino et al. Biopharmaceuticals from microorganisms: from production to purification. Brazilian Journal of Microbiology, São Paulo, v. 47, supl. 1, p. 51-63, dez. 2016. Disponível em: <>. Acesso em: 20 dez. 2017. doi:
Abstract: The use of biopharmaceuticals dates from the 19th century and within 5-10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons (IFN α, β, and γ) and growth hormones. The production of biopharmaceuticals, known as bioprocess, involves a wide range of techniques. In this review, we discuss the technology involved in the bioprocess and describe the available strategies and main advances in microbial fermentation and purification process to obtain biopharmaceuticals.
Licença:: Brazilian Journal of Microbiology - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way (CC BY NC ND). Fonte: Acesso em: 20 dez. 2017.
Appears in Collections:FAR - Artigos publicados em periódicos

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