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Title: Phylogenetic analysis reveals a high prevalence of Sporothrix brasiliensis in feline sporotrichosis outbreaks
Authors: Rodrigues, Anderson Messias
Teixeira, Marcus de Melo
Hoog, G. Sybren de
Schubach, Tânia Maria Pacheco
Pereira, Sandro Antonio
Fernandes, Geisa Ferreira
Bezerra, Leila Maria Lopes
Felipe, Maria Sueli Soares
Camargo, Zoilo Pires de
Assunto:: Fungos - doenças
Gato
Diversidade genética
Epidemias
Issue Date: 20-Jun-2013
Publisher: Plos One
Citation: RODRIGUES, Anderson Messias et al. Phylogenetic analysis reveals a high prevalence of Sporothrix brasiliensis in feline sporotrichosis outbreaks. Plos Neglected Tropical Diseases, v. 7, n. 6, Article e2281, 20 jun. 2013. Disponível em: <http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0002281>. Acesso em: 12 jun. 2017. doi: 10.1371/journal.pntd.0002281.
Abstract: Sporothrix schenckii, previously assumed to be the sole agent of human and animal sporotrichosis, is in fact a species complex. Recently recognized taxa include S. brasiliensis, S. globosa, S. mexicana, and S. luriei, in addition to S. schenckii sensu stricto. Over the last decades, large epidemics of sporotrichosis occurred in Brazil due to zoonotic transmission, and cats were pointed out as key susceptible hosts. In order to understand the eco-epidemiology of feline sporotrichosis and its role in human sporotrichosis a survey was conducted among symptomatic cats. Prevalence and phylogenetic relationships among feline Sporothrix species were investigated by reconstructing their phylogenetic origin using the calmodulin (CAL) and the translation elongation factor-1 alpha (EF1a) loci in strains originated from Rio de Janeiro (RJ, n = 15), Rio Grande do Sul (RS, n = 10), Parana´ (PR, n = 4), Sa˜o Paulo (SP, n = 3) and Minas Gerais (MG, n = 1). Our results showed that S. brasiliensis is highly prevalent among cats (96.9%) with sporotrichosis, while S. schenckii was identified only once. The genotype of Sporothrix from cats was found identical to S. brasiliensis from human sources confirming that the disease is transmitted by cats. Sporothrix brasiliensis presented low genetic diversity compared to its sister taxon S. schenckii. No evidence of recombination in S. brasiliensis was found by split decomposition or PHI-test analysis, suggesting that S. brasiliensis is a clonal species. Strains recovered in states SP, MG and PR share the genotype of the RJ outbreak, different from the RS clone. The occurrence of separate genotypes among strains indicated that the Brazilian S. brasiliensis epidemic has at least two distinct sources. We suggest that cats represent a major host and the main source of cat and human S. brasiliensis infections in Brazil.
Licença:: Copyright: 2013 Rodrigues et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI: https://dx.doi.org/10.1371/journal.pntd.0002281
Appears in Collections:CEL - Artigos publicados em periódicos

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